Hsp90: Chaperoning signal transduction

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Hsp90 as a capacitor for morphological evolution

1998 • 2,261 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Structure of TPR Domain–Peptide Complexes

2000 • 1,159 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1998 • 820 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones

1997 • 649 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

Functional requirement of p23 and Hsp90 in telomerase complexes

1999 • 538 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Crystal structure of an N-terminal fragment of the DNA gyrase B protein

1991 • 526 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

Structure of CheA, a Signal-Transducing Histidine Kinase

1999 • 471 citations

The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains

2000 • 461 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1999 • 411 citations

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

1985 • 386 citations

Crystal Structure and ATPase Activity of MutL

1998 • 374 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase

1995 • 365 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation

2000 • 328 citations

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.

1996 • 322 citations

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1996 • 309 citations

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila

1994 • 294 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

1993 • 266 citations

Protein Phosphatase 5 Is a Major Component of Glucocorticoid Receptor·hsp90 Complexes with Properties of an FK506-binding Immunophilin

1997 • 264 citations

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1994 • 257 citations

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein.

1981 • 246 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1998 • 244 citations

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.

1994 • 231 citations

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23

2000 • 230 citations

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

1990 • 229 citations

Binding of p23 and hsp90 during assembly with the progesterone receptor.

1995 • 224 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

1997 • 202 citations

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome

1997 • 193 citations

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.

1994 • 190 citations

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

1990 • 190 citations

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

1998 • 190 citations

Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery

1997 • 183 citations

Dimerization of Escherichia coli DNA-gyrase B Provides a Structural Mechanism for Activating the ATPase Catalytic Center

2000 • 183 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

Functional analysis of the hsp90-associated human peptidyl prolyl Cis/Trans isomerases FKBP51, FKBP52 and cyp40 1 1Edited by R. Huber

2001 • 178 citations

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

1992 • 177 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Ancient heat shock gene is dispensable

1988 • 173 citations

Stepwise Assembly of a Glucocorticoid Receptor·hsp90 Heterocomplex Resolves Two Sequential ATP-dependent Events Involving First hsp70 and Then hsp90 in Opening of the Steroid Binding Pocket

2000 • 168 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

Transit of pp60v-src to the plasma membrane.

1982 • 165 citations

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

1983 • 162 citations

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

2000 • 152 citations

Reconstitution of Progesterone Receptor with Heat Shock Proteins

1990 • 149 citations

Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro

1989 • 140 citations

In vitro evidence that hsp90 contains two independent chaperone sites

1997 • 137 citations

The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

1987 • 130 citations

Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.

2000 • 126 citations

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1989 • 122 citations

The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90

1995 • 122 citations

p50 Binds Directly to the Catalytic Domain of Raf as Well as to a Site on hsp90 That Is Topologically Adjacent to the Tetratricopeptide Repeat Binding Site

1998 • 119 citations

C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle 1 1Edited by R. Huber

2000 • 118 citations

Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins.

1982 • 116 citations

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.

1994 • 115 citations

Cpr6 and Cpr7, Two Closely Related Hsp90-associated Immunophilins from Saccharomyces cerevisiae, Differ in Their Functional Properties

2000 • 115 citations

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

1996 • 114 citations

Subunit composition of the molybdate-stabilized “8-9 S” nontransformed estradiol receptor purified from calf uterus.

1987 • 112 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

ATP-binding Properties of Human Hsp90

1997 • 107 citations

Two FKBP-related proteins are associated with progesterone receptor complexes.

1993 • 106 citations

The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor

1990 • 103 citations

The charged region of Hsp90 modulates the function of the N-terminal domain

1999 • 101 citations

Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation

1999 • 100 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes

1993 • 95 citations

Mineralocorticosteroid Receptor of the chick intestine

1989 • 94 citations

Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

1994 • 93 citations

Structural and functional aspects of basic helix-loop-helix protein folding by heat-shock protein 90.

1994 • 88 citations

Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.

1983 • 88 citations

Regulation of Pim-1 by Hsp90

2001 • 82 citations

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

1996 • 79 citations

Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors

1987 • 77 citations

The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:

1995 • 76 citations

Overlapping Sites of Tetratricopeptide Repeat Protein Binding and Chaperone Activity in Heat Shock Protein 90

2000 • 75 citations

The Benzoquinone Ansamycin Geldanamycin Stimulates Proteolytic Degradation of Focal Adhesion Kinase

1999 • 71 citations

A 50 Kilodalton Protein Associated with Raf and pp60^v-src Protein Kinases Is a Mammalian Homolog of the Cell Cycle Control Protein cdc37

1997 • 70 citations

Binding of p23 and hsp90 during assembly with the progesterone receptor

1995 • 67 citations

Hsp90-Mediated Folding of the Lymphoid Cell Kinase p56^lck

1996 • 66 citations

Translation of Glucocorticoid Receptor mRNA in Vitro Yields a Nonactivated Protein

1989 • 65 citations

Hsp90 Chaperone Activity Requires the Full-length Protein and Interaction among Its Multiple Domains

2000 • 55 citations

CYP2E1 Degradation by in Vitro Reconstituted Systems: Role of the Molecular Chaperone hsp90

2000 • 53 citations

Temperature-sensitive mutants of hsp82 of the budding yeast Saccharomyces cerevisiae

1994 • 52 citations

Mammalian DNA (Cytosine-5-)-methyltransferase Expressed in Escherichia coli, Purified and Characterized

1995 • 52 citations

Degradation of Heterotrimeric Gαo Subunits via the Proteosome Pathway Is Induced by the hsp90-specific Compound Geldanamycin

2000 • 48 citations

Evidence for Iterative Ratcheting of Receptor-Bound hsp70 between Its ATP and ADP Conformations during Assembly of Glucocorticoid Receptor·hsp90 Heterocomplexes

2001 • 38 citations

Heat shock-regulated production of Escherichia coli beta-galactosidase in Saccharomyces cerevisiae.

1983 • 37 citations

Demonstration that the 90-Kilodalton Heat Shock Protein is Bound to the Glucocorticoid Receptor in its 9S Nondeoxynucleic Acid Binding Form

1987 • 35 citations

The Mr approximately 90,000 heat shock protein: an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor.

1989 • 34 citations

Heat Shock Protein 90 Mediates Protein-protein Interactions between Human Aminoacyl-tRNA Synthetases

2000 • 32 citations

A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90

1991 • 29 citations

Interaction of the calcium and calmodulin regulated eEF‐2 kinase with heat shock protein 90

1994 • 24 citations

Cytosolic‐nuclear Tumor Promoter‐specific Binding Protein: Association with the 90 kDa Heat Shock Protein and Translocation into Nuclei by Treatment with 12‐O‐Tetradecanoylphorbol 13‐Acetate

1991 • 23 citations

Functional Importance of Heat Shock Protein 90 Associated with Insulin Receptor on Insulin-Stimulated Mitogenesis

1997 • 21 citations

Cell cycle‐dependent association of Gag‐Mil and hsp90

1994 • 19 citations

Some effects of growth conditions on steady state and heat shock induced htpG gene expression in continuous cultures of Escherichia coli

1990 • 13 citations

9S binding protein for androgens and progesterone.

1977 • 12 citations

What's in an Acronym?

1988 • 1 citations