Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

1998 • 522 citations

The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains

2000 • 461 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1999 • 411 citations

The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties

2000 • 358 citations

Hop Modulates hsp70/hsp90 Interactions in Protein Folding

1998 • 351 citations

Structure and in vivo function of Hsp90

2000 • 317 citations

Crystal Structures of a Schistosomal Drug and Vaccine Target: Glutathione S-Transferase fromSchistosoma japonicaand its Complex with the Leading Antischistomal Drug Praziquantel

1995 • 301 citations

Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species.

1995 • 301 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery

1997 • 260 citations

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1998 • 244 citations

The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins

1998 • 239 citations

Nucleotides and Two Functional States of hsp90

1997 • 238 citations

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.

1994 • 231 citations

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

1990 • 229 citations

Specific Binding of Tetratricopeptide Repeat Proteins to the C-terminal 12-kDa Domain of hsp90

1998 • 228 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

A versatile synthetic dimerizer for the regulation of protein–protein interactions

1997 • 203 citations

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

1998 • 190 citations

Hsp90's secrets unfold: new insights from structural and functional studies

1999 • 181 citations

Mechanism of Dimer Formation of the 90‐kDa Heat‐Shock Protein

1995 • 174 citations

The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor

1995 • 172 citations

The Role of DnaJ-like Proteins in Glucocorticoid Receptor·hsp90 Heterocomplex Assembly by the Reconstituted hsp90·p60·hsp70 Foldosome Complex

1998 • 168 citations

The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies

2000 • 165 citations

Molecular chaperones: The busy life of Hsp90

1999 • 158 citations

SBA1 Encodes a Yeast Hsp90 Cochaperone That Is Homologous to Vertebrate p23 Proteins

1998 • 154 citations

In vitro evidence that hsp90 contains two independent chaperone sites

1997 • 137 citations

Conformational stability of pGEX‐expressed Schistosoma japonicum glutathione S‐transferase: A detoxification enzyme and fusion‐protein affinity tag

1997 • 136 citations

In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus.

1994 • 125 citations

Role for Hsp90-Associated Cochaperone p23 in Estrogen Receptor Signal Transduction

1999 • 122 citations

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

1996 • 114 citations

The Common Tetratricopeptide Repeat Acceptor Site for Steroid Receptor-associated Immunophilins and Hop Is Located in the Dimerization Domain of Hsp90

1999 • 112 citations

Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins

1998 • 105 citations

The charged region of Hsp90 modulates the function of the N-terminal domain

1999 • 101 citations

Homodimerization of Soluble Guanylyl Cyclase Subunits

1999 • 93 citations

Monomer Arrangement in HSP90 Dimer as Determined by Decoration with N and C-Terminal Region Specific Antibodies

1999 • 72 citations

Glutathione S‐transferase can be used as a C‐terminal, enzymatically active dimerization module for a recombinant protease inhibitor, and functionally secreted into the periplasm of Escherichia coli

1997 • 69 citations

Mutational analysis of Hsp90α dimerization and subcellular localization: dimer disruption does not impede ‘in vivo’ interaction with estrogen receptor

1996 • 64 citations

Hsp90 Chaperone Activity Requires the Full-length Protein and Interaction among Its Multiple Domains

2000 • 55 citations

Minireview

1998 • 32 citations

Expression and Characterisation of the N-Terminal Fragment of the HsdS Subunit of M.EcoR124I

1998 • 21 citations

Identification of Dimeric Structure of Proteins by Use of the Glutathione S-Transferase-Fusion Expression System

1995 • 10 citations

A metal‐linked gapped zipper model is proposed for theh sp90‐glucocorticoid receptor interaction

1993 • 9 citations