Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Catalyzed reporter deposition, a novel method of signal amplification application to immunoassays

1989 • 765 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

p185erbB2 Binds to GRP94 in Vivo

1996 • 259 citations

A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.

1994 • 225 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

1995 • 194 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1989 • 122 citations

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.

1994 • 115 citations

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

1993 • 102 citations

Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase

1995 • 97 citations

Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor

1995 • 84 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

Binding of Benzoquinoid Ansamycins to p100 Correlates with Their Ability to Deplete the erbB2 Gene Product p185

1994 • 48 citations

Accelerated degradation of 160 kDa epidermal growth factor (EGF) receptor precursor by the tyrosine kinase inhibitor herbimycin A in the endoplasmic reticulum of A431 human epidermoid carcinoma cells

1994 • 39 citations