Multiple niches for Notch in cancer: context is everything

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Notch1 functions as a tumor suppressor in mouse skin

2003 • 957 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

2001 • 849 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

2003 • 637 citations

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

2003 • 587 citations

MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

2000 • 576 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

2003 • 541 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

2000 • 411 citations

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

2002 • 407 citations

Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling

2003 • 380 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

2002 • 354 citations

Activation of Notch signaling pathway precedes heart regeneration in zebrafish

2003 • 329 citations

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

2000 • 323 citations

Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1

2000 • 284 citations

p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro

2002 • 267 citations

Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors

2002 • 260 citations

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

2002 • 259 citations

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)

1996 • 232 citations

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1

2002 • 231 citations

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

2002 • 216 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

Structural Requirements for Assembly of the CSL·Intracellular Notch1·Mastermind-like 1 Transcriptional Activation Complex

2003 • 204 citations

Dynamics of notch expression during murine prostate development and tumorigenesis.

2001 • 202 citations

Notch signalling inDrosophila: three ways to use a pathway

1998 • 195 citations

LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway

2000 • 190 citations

Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

2002 • 189 citations

Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation

1997 • 187 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Notch signalling in hematopoiesis

2003 • 179 citations

Protein Degradation: Four E3s For The Notch Pathway

2002 • 174 citations

Activated Notch1 Inhibits p53-Induced Apoptosis and Sustains Transformation by Human Papillomavirus Type 16 E6 and E7 Oncogenes through a PI3K-PKB/Akt-Dependent Pathway

2003 • 162 citations

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

2003 • 157 citations

Ras pathway signals are required for notch-mediated oncogenesis

2000 • 150 citations

Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells

2000 • 146 citations

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis

2003 • 142 citations

Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notch^ic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

2002 • 142 citations

Ligand-Induced Signaling in the Absence of Furin Processing of Notch1

2001 • 127 citations

Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

2002 • 117 citations

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells

2003 • 116 citations

Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma

1996 • 115 citations

Notch signaling in mammary gland tumorigenesis.

2001 • 107 citations

Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition

2003 • 107 citations

HPV16 E6 and E7 oncoproteins regulate Notch‐1 expression and cooperate to induce transformation

2003 • 102 citations

A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

2001 • 101 citations

Epstein–Barr virus EBNA2 blocks Nur77- mediated apoptosis

2002 • 88 citations

Oscillations, clocks and segmentation

2003 • 84 citations

Notch signaling is necessary but not sufficient for differentiation of dendritic cells

2003 • 84 citations

Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells

2001 • 71 citations

New molecular pathways in angiogenesis

2003 • 70 citations

Notch signaling in leukemia

2001 • 68 citations

Notch signaling as a therapeutic target

2002 • 66 citations

Epstein-Barr Virus Bam HI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC

2001 • 63 citations

Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas

2003 • 58 citations

Vascular development and patterning: making the right choices

2003 • 55 citations

An Epstein-Barr Virus Protein Interacts with Notch

2001 • 53 citations

EBNA2 and Activated Notch Induce Expression of BATF

2003 • 49 citations

Notchic-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation

2000 • 44 citations