HPV16 E6 and E7 oncoproteins regulate Notch‐1 expression and cooperate to induce transformation

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1998 • 587 citations

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

2002 • 551 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

2002 • 407 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays

2000 • 292 citations

Arbiter of differentiation and death: Notch signaling meets apoptosis

1999 • 255 citations

Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

1999 • 236 citations

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.

1996 • 212 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

Human Ligands of the Notch Receptor

1999 • 182 citations

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1and results in apoptosis and tumor suppression

1998 • 175 citations

Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.

1996 • 174 citations

The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions.

1997 • 145 citations

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

2000 • 142 citations

Activated Notch1 Signaling Cooperates with Papillomavirus Oncogenes in Transformation and Generates Resistance to Apoptosis on Matrix Withdrawal through PKB/Akt

2001 • 142 citations

Neoplastic Transformation by Notch Requires Nuclear Localization

2000 • 123 citations

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells

2003 • 116 citations

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

1999 • 108 citations

Expression of an activated Notch4(int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cellsin vitro

2000 • 104 citations

Notch signaling directly controls cell proliferation in the Drosophila wing disc

2000 • 101 citations

Two Distinct Notch1 Mutant Alleles Are Involved in the Induction of T-Cell Leukemia in c-myc Transgenic Mice

2000 • 81 citations

Regulation of Transcription of the Human Presenilin-1 Gene by Ets Transcription Factors and the p53 Protooncogene

2000 • 72 citations

Toward The Rational Design of Cell Fate Modifiers Notch Signaling as a Target for Novel Biopharmaceuticals

2000 • 46 citations

Notch signaling as a target in multimodality cancer therapy.

2000 • 45 citations

Development and Assessment of a General Theory of Cervical Carcinogenesis Utilizing a Severe Combined Immunodeficiency Murine–Human Xenograft Model

2000 • 34 citations

Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers.

2000 • 32 citations

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

2000 • 29 citations