The minimal number of antigen‐major histocompatibility complex class II complexes required for activation of naive and primed T cells

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro

1996 • 241 citations

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

1996 • 201 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

1997 • 89 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway.

1992 • 78 citations

CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0⁺ than in CD45RA⁺ human T lymphocyte subsets

1993 • 56 citations

Differential activation of phospholipase C-gamma 1 and mitogen-activated protein kinase in naive and antigen-primed CD4 T cells by the peptide/MHC ligand.

1996 • 28 citations