Induction of MHC-restricted specificity and tolerance in the thymus

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Cloning of the breakpoint of an X;21 translocation associated with Duchenne muscular dystrophy

1985 • 368 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Cytotoxic T cells learn specificity for self H–2 during differentiation in the thymus

1978 • 219 citations

The Origin and Mechanism of the Allograft Reaction

1977 • 217 citations

Effector Mechanisms in Allograft Rejection

1986 • 202 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

Expression of MHC Antigens by Mouse Thymic Dendritic Cells

1979 • 191 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow cells from one parental strain.

1975 • 140 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

1985 • 126 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells.

1985 • 110 citations

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

1986 • 109 citations

Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ

1985 • 106 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens.

1983 • 80 citations

Recognition and Regulation in Cell-Mediated Immunity

1985 • 79 citations

Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera.

1978 • 74 citations

Early appearance of donor-type antigen-presenting cells in the thymuses of 1200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene products.

1983 • 68 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.

1983 • 49 citations

T cell specificity in twice-irradiated F1----parent bone marrow chimeras: failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction.

1986 • 48 citations

Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.

1985 • 46 citations

Reduced expression of Ia antigens by thymic epithelial cells of aged mice.

1984 • 40 citations

Split tolerance induced by chick embryo thymic epithelium allografted to embryonic recipients.

1986 • 37 citations

Strain difference in the radiosensitivity of immunocompetent cells and its influence on the residual host-vs-graft reaction in lethally irradiated mice grafted with semiallogeneic bone marrow.

1985 • 35 citations

Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells.

1982 • 33 citations

Acquisition of the T cell repertoire

1978 • 30 citations

Exogenous control of I-A expression in fetal thymus explants.

1986 • 30 citations

Transplantation tolerance induced in foetal mouse thymus in vitro

1978 • 29 citations

Thymic epithelium. I. Lymphoid-free organ cultures grafted in syngeneic intact mice.

1985 • 16 citations