Alterations in CD4-Binding Regions of the MHC Class II Molecule I-Ek Do Not Impede CD4+ T Cell Development

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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

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1991 • 673 citations

The class II molecules of the human and murine major histocompatibility complex

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Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

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CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

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1987 • 505 citations

Crystal structure of the complex between human CD8αα and HLA-A2

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A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

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1986 • 375 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

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1996 • 326 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

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1987 • 276 citations

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1992 • 272 citations

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1987 • 265 citations

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1982 • 244 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

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MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

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1988 • 203 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

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Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

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1996 • 199 citations

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1994 • 185 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

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1986 • 159 citations

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1984 • 131 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

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Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

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Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.

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Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes.

1988 • 89 citations

Role of CD4 in thymocyte selection and maturation.

1989 • 88 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

1991 • 81 citations

CD8 Lineage Commitment in the Absence of CD8

1997 • 74 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

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Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice.

1985 • 70 citations

Engagement of CD4 and CD8 accessory molecules is required for T cell maturation.

1989 • 70 citations

Mouse CD4 binds MHC class II with extremely low affinity

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1996 • 57 citations

Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation

1989 • 57 citations

Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens

1988 • 50 citations

Peptide-Induced Positive Selection of TCR Transgenic Thymocytes in a Coreceptor-Independent Manner

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Regulation of T helper‐B lymphocyte adhesion through CD4‐HLA class II interaction

1990 • 40 citations

Immune deficiency due to high copy numbers of an Ak beta transgene.

1990 • 38 citations

Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody.

1989 • 32 citations

Purified beta-chain of MHC class II binds to CD4 molecules on transfected HeLa cells.

1993 • 32 citations

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes.

1992 • 31 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1998 • 31 citations

Isotypic residues in the membrane proximal domain of MHC class II beta-chains control activation of CD4+ T cells.

1993 • 13 citations

Structurally similar TCRs differ in their efficiency of positive selection.

1997 • 13 citations

The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.

1990 • 11 citations

Enhanced T Cell Maturation and Altered Lineage Commitment in T Cell Receptor/CD4-Transgenic Mice

1995 • 7 citations

Alterations in CD4 dependence accompany T cell development and differentiation

1996 • 7 citations