A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

The somatic generation of immune recognition

1971 • 974 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

1983 • 264 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum

1983 • 217 citations

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

1983 • 209 citations

Antigen Receptors of T Helper Cells

1977 • 200 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation

1982 • 170 citations

Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.

1984 • 167 citations

Localization of a T-cell receptor diversity-region element

1984 • 159 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen.

1983 • 101 citations

T-cell idiotypes are linked to immunoglobulin heavy chain genes

1976 • 101 citations

Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor.

1984 • 99 citations

Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments.

1980 • 73 citations

Membrane-bound ribosomes of myeloma cells. IV. mRNA complexity of free and membrane-bound polysomes.

1981 • 65 citations

Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones.

1982 • 63 citations

Construction of a cloned library of expressed embryonic gene sequences from Xenopus laevis

1980 • 58 citations

Thy-1 cDNA sequence suggests a novel regulatory mechanism

1983 • 57 citations

T-Lymphocyte Clones

1983 • 56 citations

Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts.

1983 • 54 citations

T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments.

1983 • 54 citations

Murine T cell receptor beta chain is encoded on chromosome 6.

1984 • 51 citations

Monoclonal antibodies specific for a murine cytotoxic T-lymphocyte clone.

1984 • 51 citations

Kappa-chain allotypes and isotypes in the rabbit: cDNA sequences of clones encoding b9 suggest an evolutionary pathway and possible role of the interdomain disulfide bond in quantitative allotype expression.

1984 • 51 citations

Immunology: The T-lymphocyte antigen receptor — elusive no more

1984 • 37 citations

A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.

1982 • 36 citations

T-Cell and B-Cell Responses to Viral Antigens at the Clonal Level

1983 • 33 citations

Three-receptor, clonal expansion model for selection of self-recognition in the thymus

1980 • 31 citations

The isolation of cloned cDNA sequen which are differentially expressed in human lymphocytes and fibroblasts

1980 • 29 citations

Two Types of DNA Rearrangements in Immunoglobulin Genes

1981 • 25 citations

Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus.

1981 • 25 citations

Genes for the mouse T cell alloantigens Tpre, Tthy, Tind, and Tsu are closely linked near Igh on chromosome 12.

1984 • 20 citations

Immunoglobulin Gene Expression by T Lymphocytes

1983 • 13 citations

THE ISOLATION OF B AND T CELL-SPECIFIC GENES

1982 • 12 citations

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