Naturally Occurring Low Affinity Peptide/MHC Class I Ligands Can Mediate Negative Selection and T Cell Activation

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Positive Selection of Thymocytes

1995 • 604 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

T Cell Selection in the Thymus

1988 • 405 citations

The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

1996 • 332 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry

1994 • 319 citations

Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.

1980 • 306 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis

1982 • 219 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

Monoclonal antibodies to mouse MHC antigens

1984 • 166 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Differential transport requirements of HLA and H-2 class I glycoproteins

1989 • 143 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

1996 • 135 citations

In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells.

1992 • 134 citations

A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.

1996 • 131 citations

A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

1993 • 129 citations

The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.

1991 • 122 citations

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

1995 • 121 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

1994 • 95 citations

Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions.

1992 • 81 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1993 • 71 citations

Selecting the T Cell Receptor Repertoire

1994 • 71 citations

Expression of complete transplantation antigens by mammalian cells transformed with truncated class I genes

1983 • 70 citations

Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells

1990 • 54 citations

Permissive recognition during positive selection

1996 • 52 citations

Alloreactive 2C T cells recognize a self peptide in the context of the mutant Kbm3 molecule.

1995 • 38 citations

Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion

1994 • 33 citations

A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and a nonself class I MHC protein

1994 • 30 citations

Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions.

1995 • 25 citations

Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection.

1995 • 10 citations