Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDR

1996 • 725 citations

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1999 • 563 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

1999 • 501 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.

1991 • 325 citations

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1997 • 305 citations

Phospholipase C-γ as a Signal-Transducing Element

1999 • 242 citations

Assays for angiogenesis: A review

1991 • 202 citations

Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2

1999 • 160 citations

Enhanced chemiluminescent method for the detection of DNA dot-hybridization assays

1985 • 154 citations

The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ

1997 • 124 citations

Identification of Vascular Endothelial Growth Factor Receptor-1 Tyrosine Phosphorylation Sites and Binding of SH2 Domain-containing Molecules

1998 • 112 citations

Signal relays in the VEGF system

1999 • 98 citations

Ligand-induced interaction between .alpha.- and .beta.-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation

1991 • 93 citations

Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB.

1991 • 87 citations

Signal relays in the VEGF system

1999 • 82 citations

The Proliferative Effect of Vascular Endothelial Growth Factor Requires Protein Kinase C-α and Protein Kinase C-ζ

1999 • 78 citations

Increased mitogenicity of an αβ heterodimeric PDGF receptor complex correlates with lack of RasGAP binding

1999 • 67 citations

KDR activation is crucial for VEGF₁₆₅-mediated Ca²⁺ mobilization in human umbilical vein endothelial cells

1999 • 41 citations

Dual effects of heparin on VEGF binding to VEGF receptor-1 and transduction of biological responses.

1999 • 28 citations

The Mechanics of Vascular Cell Motility

1998 • 24 citations