New insights into the pathophysiological role for cytokines in heart failure

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

1996 • 1,182 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

1998 • 602 citations

Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium

1998 • 534 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Effects of Vesnarinone on Morbidity and Mortality in Patients with Heart Failure

1993 • 482 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Cytokine Gene Expression After Myocardial Infarction in Rat Hearts

1998 • 418 citations

Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

1997 • 364 citations

Elevated Circulating Levels of C-C Chemokines in Patients With Congestive Heart Failure

1998 • 357 citations

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

1997 • 324 citations

Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy

1995 • 309 citations

Hemodynamic Regulation of Tumor Necrosis Factor-α Gene and Protein Expression in Adult Feline Myocardium

1997 • 284 citations

Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.

1995 • 273 citations

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

1993 • 242 citations

Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy

1998 • 218 citations

Effect of Amiodarone on Clinical Status and Left Ventricular Function in Patients With Congestive Heart Failure

1996 • 217 citations

Circulating Interleukin-6 in Severe Heart Failure

1997 • 211 citations

Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats

1994 • 206 citations

Mechanical forces and their second messengers in stimulating cell growth in vitro

1992 • 201 citations

Dilated Cardiomyopathy Associated With Hepatitis C Virus Infection

1995 • 198 citations

Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture.

1995 • 193 citations

Persistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice

1996 • 171 citations

Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload

1997 • 163 citations

Cardiac Endothelin-1 Plays a Critical Role in the Functional Deterioration of Left Ventricles During the Transition From Compensatory Hypertrophy to Congestive Heart Failure in Salt-Sensitive Hypertensive Rats

1998 • 163 citations

Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.

1994 • 160 citations

Plasma Levels of the Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 are Elevated in Patients with Acute Myocardial Infarction

1997 • 156 citations

Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes.

1994 • 154 citations

Cyclic Stretch Upregulates Production of Interleukin-8 and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in Human Endothelial Cells

1998 • 148 citations

How should physicians view heart failure? The philosophical and physiological evolution of three conceptual models of the disease

1993 • 142 citations

Interleukin-1 in Myocardium and Coronary Arteries of Patients with Dilated Cardiomyopathy

1998 • 136 citations

Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

1987 • 120 citations

Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.

1998 • 114 citations

Role of Cytokines in the Mechanism of Action of Amlodipine: The PRAISE Heart Failure Trial

1997 • 114 citations

Adenosine Inhibits Lipopolysaccharide-Induced Cardiac Expression of Tumor Necrosis Factor-α

1998 • 114 citations

Effects of Tumor Necrosis Factor Gene Polymorphisms on Patients With Congestive Heart Failure

1998 • 104 citations

Amiodarone Inhibits Production of Tumor Necrosis Factor-α by Human Mononuclear Cells

1997 • 101 citations

The effect of renin–angiotensin system inhibitors on pro‐ and anti‐inflammatory cytokine production

1998 • 98 citations

Modulation of Cytokine Production and Protection Against Lethal Endotoxemia by the Cardiac Glycoside Ouabain

1997 • 94 citations

Beneficial Effects of Amlodipine in a Murine Model of Congestive Heart Failure Induced by Viral Myocarditis

1997 • 85 citations

Chronic Hypoxia Modulates the Interleukin-1β–Stimulated Inducible Nitric Oxide Synthase Pathway in Cardiac Myocytes

1997 • 70 citations

Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Suppression of natural killer cell activity and tumor necrosis factor-alpha production.

1994 • 69 citations

Cytokine and murine coxsackievirus B3 myocarditis. Interleukin-2 suppressed myocarditis in the acute stage but enhanced the condition in the subsequent stage.

1994 • 65 citations

A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure

1990 • 51 citations

Inhibition of cytokine production by a new inotropic agent, vesnarinone, in human lymphocytes, T cell line, and monocytic cell line

1994 • 39 citations

Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage, cytokines and hypoxia in rats

1994 • 38 citations

Denopamine, a β1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart

1998 • 26 citations

Vesnarinone: A potential cytokine inhibitor

1996 • 18 citations

Vesnarinone Limits Infarct Size via Adenosine-Dependent Mechanisms in the Canine Heart

1997 • 16 citations

Interaction of Cytotoxic T Lymphocytes and Guinea Pig Ventricular Myocytes

1996 • 16 citations

Indirect inhibition of myocyte RNA and protein synthesis by interleukin-1

1990 • 10 citations

Prevention of ventricular remodeling

1998 • 2 citations