Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Suppression of natural killer cell activity and tumor necrosis factor-alpha production.

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Effects of Vesnarinone on Morbidity and Mortality in Patients with Heart Failure

1993 • 482 citations

Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

1990 • 471 citations

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

1981 • 424 citations

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

1988 • 397 citations

Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists.

1992 • 385 citations

Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin.

1991 • 256 citations

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

1993 • 242 citations

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

1987 • 235 citations

An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus.

1982 • 194 citations

Mechanisms of Activation of Human Natural Killer Cells Against Tumor and Virus‐infected Cells

1979 • 191 citations

Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle.

1986 • 175 citations

Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

1987 • 135 citations

Effects of prednisolone on acute viral myocarditis in mice

1986 • 130 citations

An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice.

1982 • 127 citations

Myocarditis and cardiomyopathy

1984 • 116 citations

Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus.

1986 • 107 citations

Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart.

1987 • 89 citations

The effects of cyclosporine on acute murine Coxsackie B3 myocarditis.

1986 • 87 citations

Coxsackievirus B3-induced production of tumor necrosis factor-alpha, IL-1 beta, and IL-6 in human monocytes.

1992 • 86 citations

Treatment of chronic heart failure

1992 • 85 citations

Virus and the Heart

1971 • 78 citations

Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3.

1991 • 77 citations

Derivation and characterization of an efficiently myocarditic reovirus variant

1989 • 71 citations

In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis.

1987 • 63 citations

Usefulness of OPC-8212, a quinolinone derivative, for chronic congestive heart failure in patients with ischemic heart disease or idiopathic dilated cardiomyopathy

1991 • 61 citations

Anti-tumor necrosis factor antibodies suppress cell-mediated immunity in vivo.

1992 • 61 citations

Acute hemodynamic effects of a new inotropic agent, OPC-8212, on severe congestive heart failure

1986 • 39 citations

Acute hemodynamic effects of a new inotropic agent (OPC-8212) in patients with congestive heart failure

1987 • 34 citations

What do the newer inotropic drugs have to offer?

1992 • 33 citations

Evaluation of a new inotropic agent, OPC-8212, in patients with dilated cardiomyopathy and heart failure

1988 • 32 citations

The inhibitory effects of a positive inotropic quinolinone derivative, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), on bone-marrow progenitor cells and peripheral lymphocytes

1992 • 25 citations

Some aspects of pharmacokinetic and biotransformation differences in humans and mammal animals.

1978 • 24 citations

Pharmacokinetic Profile of OPC‐8212 in Humans: A New, Nonglycosidic, Inotropic Agent

1988 • 22 citations

Stimulation of Macrophages by Endotoxin Results in the Reactivation of a Persistent Herpes Simplex Virus Infection

1990 • 8 citations

Concepts of molecular pathogenesis

1990 • 1 citations