The Pathogenesis of Sepsis

Principles and Practice of Infectious Diseases.

1991 • 12,590 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Interleukin-1

1984 • 1,625 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Perspectives in platelet-activating factor research.

1987 • 1,383 citations

Gram-negative bacteremia

1980 • 1,341 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Neutrophils in Human Diseases

1987 • 852 citations

Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria

1989 • 852 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

The Effects of High-Dose Corticosteroids in Patients with Septic Shock

1984 • 761 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Monocytes and Macrophages

1988 • 711 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Sepsis syndrome

1989 • 523 citations

Peptide Regulatory Factors

1989 • 498 citations

CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

1988 • 490 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis

1990 • 470 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Lymphokines

1987 • 459 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

New Concepts on the Pathogenesis of Fever

1988 • 373 citations

Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit

1990 • 367 citations

Coagulase-Negative Staphylococcal Bacteremia

1989 • 354 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Tumor Necrosis Factor Causes Increased Pulmonary Permeability and Edema: Comparison to Septic Acute Lung Injury

1988 • 338 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

Plasma tumor necrosis factor and mortality in critically ill septic patients

1989 • 324 citations

Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

1987 • 279 citations

Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung

1990 • 266 citations

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

1988 • 260 citations

Intravascular coagulation associated with the adult respiratory distress syndrome

1976 • 254 citations

Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs

1983 • 243 citations

The Acute Metabolic Effects of Tumor Necrosis Factor Administration in Humans

1987 • 236 citations

Septic shock. Hemodynamics and pathogenesis.

1983 • 229 citations

Plasma Kallikrein and Hageman Factor in Gram-Negative Bacteremia

1970 • 221 citations

IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils.

1990 • 217 citations

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

1980 • 212 citations

Biological Effects of Bacterial Endotoxins in Man

1973 • 208 citations

TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1989 • 202 citations

Characterization of the antitumor activities of human tumor necrosis factor-alpha and the comparison with other cytokines: induction of tumor-specific immunity.

1987 • 200 citations

Gram-Negative Sepsis

1991 • 200 citations

Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages.

1986 • 187 citations

Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat

1987 • 185 citations

Cachetin/TNF-α in Septic Shock and Septic Adult Respiratory Distress Syndrome

1988 • 183 citations

Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts.

1987 • 171 citations

A Circulating Myocardial Depressant Substance is Associated with Cardiac Dysfunction and Peripheral Hypoperfusion (Lactic Acidemia) in Patients with Septic Shock

1989 • 166 citations

Manifestations of Sepsis

1987 • 164 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance

1990 • 156 citations

Septic Shock

1983 • 155 citations

Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.

1990 • 149 citations

Tumor necrosis factor in the serum of patients with systemic lupus erythematosus

1989 • 149 citations

Complement in the Pathophysiology of Human Disease

1987 • 148 citations

Proteolytic inactivation of plasma C1- inhibitor in sepsis.

1989 • 141 citations

Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide System

1979 • 136 citations

Detection of Tumour Necrosis Factor‐Like Cytotoxicity in Serum from Patients With Septicaemia but Not from Untreated Cancer Patients

1986 • 130 citations

Leukotriene production and inactivation by normal, chronic granulomatous disease and myeloperoxidase-deficient neutrophils.

1983 • 128 citations

Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage.

1987 • 128 citations

SPECIFIC INTERLEUKIN-1 INHIBITOR IN SERUM AND URINE OF CHILDREN WITH SYSTEMIC JUVENILE CHRONIC ARTHRITIS

1987 • 125 citations

Efficacy of a Monoclonal Antibody Directed against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection with Pseudomonas aeruginosa

1990 • 123 citations

Tumor necrosis factor is the major monocyte product that increases complement receptor expression on mature human neutrophils

1988 • 123 citations

Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells.

1990 • 119 citations

Generation of a leukotriene-like substance from porcine vascular and other tissues

1983 • 118 citations

Degranulating Stimuli Decrease the Negative Surface Charge and Increase the Adhesiveness of Human Neutrophils

1980 • 113 citations

Tumor Necrosis Factor- Plays a Role in Host Defense against Histoplasma capsulatum

1990 • 110 citations

Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

1985 • 109 citations

Endothelium-derived relaxing factor

1988 • 109 citations

The role of platelets in the adult respiratory distress syndrome. Culprits or bystanders?

1987 • 102 citations

Spontaneous and Stimulated Release of Tumor Necrosis Factor-alpha (TNF) from Blood Monocytes of Miners with Coal Workers' Pneumoconiosis

1988 • 100 citations

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome

1989 • 77 citations

Mechanism of Platelet Activating Factor-induced Bronchoconstriction in Humans

1988 • 77 citations

Plasma Tumor Necrosis Factor Levels in Patients With Presumed Sepsis

1989 • 74 citations

Serum Tumor Necrosis Factor Levels and Disease Dissemination in Leprosy and Leishmaniasis

1990 • 74 citations

Neutrophils autoinactivate secretory products by myeloperoxidase- catalyzed oxidation

1985 • 73 citations

Interleukin 1-induced pathophysiology: Induction of cytokines, development of histopathologic changes, and immunopharmacologic intervention

1989 • 68 citations

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

1990 • 67 citations

C5a-induced hemodynamic and hematologic changes in the rabbit. Role of cyclooxygenase products and polymorphonuclear leukocytes.

1987 • 66 citations

Myocardial Dysfunction in Sepsis Recent Insights

1989 • 63 citations

Regulation of serum tumor necrosis factor in glucocorticoid-sensitive and -resistant rodent endotoxin shock models

1989 • 61 citations

Prostaglandins, cyclo-oxygenase inhibitors, and thromboxane synthetase inhibitors in the pathogenesis of multiple systems organ failure.

1989 • 55 citations

Pathophysiological mechanisms of sudden death induced by platelet activating factor

1984 • 53 citations

Acute Lung Injury in Septic Shock

1989 • 52 citations

Monoclonal Antibody to Endotoxin Core Protects Mice from Escherichia coli Sepsis by a Mechanism Independent of Tumor Necrosis Factor and Interleukin-6

1990 • 51 citations

Evidence for the involvement of a plasma kallikrein‐kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats

1989 • 51 citations

Anaphylatoxin‐induced shock and two patterns of anaphylactic shock: Hemodynamics and mediators*

1979 • 50 citations

Tumor necrosis factor-α and interleukin 6 synergistically induce T cell growth

1990 • 50 citations

Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A

1989 • 48 citations

Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia.

1984 • 46 citations

Prostaglandins, Cyclo-oxygenase Inhibitors, and Thromboxane Synthetase Inhibitors in the Pathogenesis of Multiple Systems Organ Failure

1989 • 45 citations

A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases?

1985 • 44 citations

Naloxone therapy of human septic shock

1985 • 42 citations

Relationships between tumour necrosis factor, eicosanoids and platelet‐activating factor as mediators of endotoxin‐induced shock in mice

1990 • 42 citations

Cytokine Networking in Lung Inflammation

1990 • 41 citations

Plasma Kallikrein-Kinin System in Septicemia

1983 • 39 citations

Interleukin 1 secretion from human alveolar macrophages in lung disease

1986 • 39 citations

Alveolar macrophage function in a canine model of endotoxin-induced lung injury.

1986 • 36 citations

Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock

1988 • 36 citations

Immune Cellular interactions During Sepsis and Septic injury

1989 • 36 citations

Endothelial cell biology in relation to current concepts of vessel wall structure and function.

1991 • 36 citations

Neutrophil aggregating activity and septic shock in humans: Neutrophil aggregation by a C5a-like material occurs more frequently than complement component depletion and correlates with depression of systemic vascular resistance

1988 • 31 citations

Effects of in vivo 'priming' on endotoxin-induced hypotension and tissue injury. The role of PAF and tumor necrosis factor.

1990 • 30 citations

Induction of Tissue Injury and Altered Cardiovascular Performance by Platelet-Activating Factor: Relevance to Multiple Systems Organ Failure

1989 • 30 citations

Involvement of endothelin in the regulation of human vascular tonus

1991 • 28 citations

Role of platelet-activating factor in adriamycin-induced nephropathy in rats

1987 • 28 citations

Textbook of Critical Care Medicine

1992 • 27 citations

Immunotherapeutic advances in the treatment of gram-negative bacterial sepsis

1987 • 25 citations

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

1989 • 24 citations

Cachectin/TNF: A Macrophage Protein That Induces Cachexia and Shock

1988 • 20 citations

Effect of Endotoxin-induced Cell Injury on 70-kD Heat Shock Proteins in Bovine Lung Endothelial Cells

1990 • 20 citations

Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis

1989 • 19 citations

The Presence of Platelet-activating Factor Associated with Eosinophil and/or Neutrophil Accumulations in the Pleural Fluids

1990 • 18 citations

Involvement of Endogenous Opiates in Glucose-Stimulated Hyperinsulinism of Canine Endotoxin Shock: Inhibition by Naloxone

1987 • 7 citations

Plasma beta-endorphin-like-immunoreactivity levels and hemodynamics in patients with septic shock.

1985 • 4 citations