Proteolytic inactivation of plasma C1- inhibitor in sepsis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

The effects of bacterial endotoxins on host mediation systems. A review.

1978 • 648 citations

Gram-negative bacteremia

1980 • 600 citations

Complement-Induced Granulocyte Aggregation

1980 • 520 citations

The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985 • 514 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

The role of cachectin/TNF in endotoxic shock and cachexia

1988 • 335 citations

The coagulation-kinin pathway of human plasma

1987 • 263 citations

Hemodynamic determinants of mortality in human septic shock

1986 • 243 citations

Activation of the Properdin Pathway of Complement in Patients with Gram-Negative Bacteremia

1975 • 235 citations

Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects

1977 • 226 citations

Assay and Properties of Serum Inhibitor of C'1-Esterase

1959 • 224 citations

Plasma Kallikrein and Hageman Factor in Gram-Negative Bacteremia

1970 • 221 citations

Human plasma kallikrein releases neutrophil elastase during blood coagulation.

1983 • 221 citations

Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin.

1975 • 219 citations

Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis

1989 • 218 citations

Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma

1982 • 218 citations

The coagulation-kinin pathway of human plasma

1987 • 218 citations

Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.

1982 • 207 citations

The regulation of human factor XIIa by plasma proteinase inhibitors.

1985 • 205 citations

Prekallikrein Activation and High-Molecular-Weight Kininogen Consumption in Hereditary Angioedema

1983 • 204 citations

Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(- )-inhibitor complexes in sepsis

1988 • 196 citations

Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.

1984 • 180 citations

Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery.

1985 • 176 citations

Prevalence of Serum Antibody to Staphylococcal Enterotoxin F among Wisconsin Residents: Implications for Toxic-Shock Syndrome

1983 • 173 citations

Inactivation of kallikrein in human plasma.

1983 • 161 citations

Serum Complement Levels in Bacteremia Due to Gram-Negative Organisms

1973 • 159 citations

Interaction of ¹²⁵I‐labelled complement subcomponents Cr and Cs with protease inhibitors in plasma

1979 • 147 citations

Contribution of Kinins to Endotoxin Shock in Unanesthetized Rhesus Monkeys

1968 • 140 citations

Purified plasma factor XIIa aggregates human neutrophils and causes degranulation

1986 • 128 citations

Anaphylatoxins: Possible Roles in Disease

1986 • 121 citations

Peripheral vascular resistance in septic shock: its relation to outcome

1988 • 120 citations

The Hemodynamic Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1988 • 118 citations

Activation and Inhibition of Hageman Factor-Dependent Pathways and the Complement System in Uncomplicated Bacteremia or Bacterial Shock

1985 • 114 citations

Human C.lovin.1 inhibitor: improved isolation and preliminary structural characterization

1983 • 112 citations

Primary structure of the reactive site of human C1-inhibitor.

1985 • 107 citations

Human plasma kallikrein. A rapid purification method with high yield

1981 • 96 citations

Activation of the contact system of plasma proteolysis in the adult respiratory distress syndrome.

1988 • 89 citations

Activation of Purified Human Plasma Prekallikrein Triggered by Cell Wall Fractions of Escherichia coli and Staphylococcus aureus

1983 • 84 citations

Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension

1986 • 81 citations

Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients.

1986 • 78 citations

Plasma Kallikrein Activation and Inhibition during Typhoid Fever

1978 • 78 citations

A C1-inhibitor-complex assay (INCA): a method to detect C1 activation in vitro and in vivo.

1981 • 73 citations

Kinin activation in the blood of patients with sepsis.

1976 • 67 citations

Detection of Activation of the Contact System of Coagulation In Vitro and In Vivo: Quantitation of Activated Hageman Factor-C1-Inhibitor and Kallikrein-C1-Inhibitor Complexes by Specific Radioimmunoassays

1987 • 54 citations

Biochemistry and Pathophysiology of Human Cl Inhibitor: Current Issues

1985 • 52 citations

Effects of Bradykinin on Forearm Venous Tone and Vascular Resistance in Man

1965 • 52 citations

Serum inhibitor of C'1-esterase in health and disease.

1966 • 51 citations

Interaction of human plasma kallikrein and its light chain with C.hivin.1 inhibitor

1983 • 48 citations

Expression of functional human C1 inhibitor in COS cells.

1988 • 44 citations

Inactivation of C-1 inhibitor by proteases: demonstration by a monoclonal antibody of a neodeterminant on inactivated, non-complexed C-1 inhibitor.

1987 • 43 citations

Low molecular weight C1q in systemic lupus erythematosus.

1985 • 42 citations

Enzymatic inactivation of human plasma C-inhibitor and α1-antichymotrypsin by pseudomonas aeruginosa proteinase and elastase

1984 • 42 citations

Plasma Kallikrein-Kinin System in Patients with Uncomplicated Sepsis and Septic Shock-Comparison with Cardiogenic Shock

1987 • 42 citations

Participation and interactions of neutrophil elastase in haemostatic disorders of patients with severe infections

1987 • 41 citations

Studies on components of the plasma kallikrein-kinin system in plasma samples from normal individuals and patients with septic shock.

1980 • 40 citations

Inhibition of human blood coagulation factor XIa by C.hivin.1 inhibitor

1988 • 33 citations

Human plasma kallikrein and C1 inhibitor form a complex possessing an epitope that is not detectable on the parent molecules: demonstration using a monoclonal antibody.

1985 • 30 citations

Structural and circular-dichroism studies on the interaction between human C̅1-esterase inhibitor and C̅1s

1983 • 24 citations

Acquired C1 esterase-inhibitor deficiency: Case report with emphasis on complement and kallikrein activation during two patterns of clinical manifestations

1986 • 21 citations

Interactions of plasma kallikrein and C1-s with normal and dysfunctional C1(-)-inhibitor proteins from patients with hereditary angioneurotic edema: analytic gel studies

1987 • 13 citations

Purified plasma factor XIIa aggregates human neutrophils and causes degranulation

1986 • 9 citations

Heparin-stimulated modification of C1-inhibitor by subcomponent C1s of human complement.

1983 • 9 citations

Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(- )-inhibitor complexes in sepsis

1988 • 3 citations