Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

1985 • 2,210 citations

Final Report on the Aspirin Component of the Ongoing Physicians' Health Study

1989 • 2,180 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death

1984 • 1,700 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Cardiovascular Effects of n-3 Fatty Acids

1988 • 1,185 citations

Randomised trial of prophylactic daily aspirin in British male doctors

1988 • 1,178 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

The Composition of Food Consumed by Greenland Eskimos

1976 • 964 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Fatty acid composition of the plasma lipids in Greenland Eskimos

1975 • 883 citations

Medicine and the Law

1969 • 849 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

1987 • 703 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

LEUKOKINETIC STUDIES. IV. THE TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND THE GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS*

1961 • 626 citations

Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts

1988 • 540 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Role of leukocytes in response to acute myocardial ischemia and reflow in dogs

1986 • 507 citations

Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.

1984 • 470 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina

1974 • 461 citations

Amphipathic metabolites and membrane dysfunction in ischemic myocardium.

1984 • 445 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

Primary Prevention With Metoprolol in Patients With Hypertension

1988 • 388 citations

Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty Acids

1988 • 385 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Incidence of non-melanocytic skin cancer treated in Australia

1988 • 360 citations

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro.

1987 • 358 citations

Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets

1983 • 353 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Flow-dependent coronary artery dilatation in humans.

1989 • 333 citations

EXPERIMENTAL ARTERIOSCLEROSIS

1972 • 327 citations

Effect of Cholesterol on Production of Thromboxane B₂by Platelets in Vitro

1980 • 322 citations

IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY)

1984 • 319 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

Platelets, endothelium, and vasospasm.

1985 • 301 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Sensitivity and specificity of intracoronary injection of acetylcholine for the induction of coronary artery spasm

1988 • 289 citations

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.

1986 • 283 citations

Neutrophil function in ischemic heart disease.

1989 • 278 citations

The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro

1985 • 268 citations

Nitroglycerin Stimulates Synthesis of Prostacyclin by Cultured Human Endothelial Cells

1981 • 252 citations

Is Variant Angina the Coronary Manifestation of a Generalized Vasospastic Disorder?

1981 • 247 citations

Neutrophils as potential participants in acute myocardial ischemia: Relevance to reperfusion

1988 • 240 citations

Effect of nifedipine on recurrent stenosis after percutaneous transluminal coronary angioplasty

1986 • 237 citations

Propranolol in hypertension: A study of long-term therapy, 1964–1970

1972 • 218 citations

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 • 205 citations

Acute effects of transluminal angioplasty in three experimental models of atherosclerosis.

1982 • 201 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

Enhancement of platelet function by superoxide anion.

1977 • 186 citations

Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

1980 • 185 citations

Effect of Aspirin on Thrombin-Induced Adherence of Platelets to Cultured Cells from the Blood Vessel Wall

1978 • 184 citations

Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors.

1983 • 179 citations

The adhesive interaction between polymorphonuclear leukocytes and endothelial cells in vitro

1978 • 172 citations

Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.

1986 • 169 citations

TOXICITY OF INSECTICIDES

1964 • 166 citations

Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries.

1987 • 166 citations

Generation of superoxide radicals by human peripheral neutrophils activated by chemotactic factor. Evidence for the role of calcium.

1979 • 156 citations

Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion.

1989 • 146 citations

Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets

1985 • 143 citations

Platelet-derived growth factor promotes polymorphonuclear leukocyte activation

1984 • 132 citations

Diminished Polymorphonuclear Leukocyte Adherence

1980 • 128 citations

Medical approaches to prevention of restenosis after coronary angioplasty

1987 • 128 citations

ANTI-PLATELET ACTIVITY OF BETA-ADRENERGIC ANTAGONISTS: INHIBITION OF THROMBOXANE SYNTHESIS AND PLATELET AGGREGATION IN PATIENTS RECEIVING LONG-TERM PROPRANOLOL TREATMENT

1981 • 119 citations

Generation of a leukotriene-like substance from porcine vascular and other tissues

1983 • 118 citations

Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs.

1988 • 112 citations

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

1985 • 111 citations

Endothelium-derived relaxing factor

1988 • 109 citations

Endothelium-derived contracting factor: endothelin and/or superoxide anion?

1988 • 109 citations

Human β-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells

1979 • 108 citations

Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor.

1981 • 106 citations

Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease

1988 • 105 citations

Mechanism of transluminal angioplasty

1984 • 102 citations

The salvage of ischaemic myocardium by BW755C in anaesthetised dogs

1982 • 102 citations

Mechanism of angioplasty and its relation to restenosis

1987 • 100 citations

Synergistic inhibition of platelet aggregation by endothelium derived relaxing factor and prostacyclin

1988 • 99 citations

Canine myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine.

1986 • 95 citations

Neutrophil Depletion Suppresses 111In-Labeled Platelet Accumulation in Infarcted Myocardium

1985 • 95 citations

Protection by superoxide dismutase from myocardial dysfunction and attenuation of vasodilator reserve after coronary occlusion and reperfusion in dog.

1989 • 92 citations

Synergistic disaggregation of platelets by tissue-type plasminogen activator, prostaglandin E1, and nitroglycerin.

1989 • 90 citations

Inhibition of cyclic flow variations in stenosed canine coronary arteries by thromboxane A2/prostaglandin H2 receptor antagonists.

1986 • 89 citations

Effects by nifedipine (Adalat®) on platelet function in vitro and in vivo

1981 • 86 citations

Superoxide radical-mediated endothelial injury and vasoconstriction of rat thoracic aortic rings.

1990 • 84 citations

Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.

1988 • 84 citations

Cholesterol and atheroma lipids activate complement and stimulate granulocytes. A possible mechanism for amplification of ischemic injury in atherosclerotic states.

1981 • 82 citations

Canine Myocardial Reperfusion Injury

1986 • 78 citations

Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis.

1988 • 74 citations

Herpes Simplex Virus Glycoprotein D: Human Monoclonal Antibody Produced by Bone Marrow Cell Line

1983 • 74 citations

Influence of thromboxane inhibition on the severity of myocardial ischemia in cats

1980 • 73 citations

Amelioration of Endothelial Abnormalities by Prednisone in Experimental Thrombocytopenia in the Rabbit

1977 • 73 citations

Platelet function studies in coronary heart disease. IX. Increased platelet prostaglandin generation and abnormal platelet sensitivity to prostacyclin and endoperoxide analog in angina pectoris

1980 • 72 citations

Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism.

1988 • 71 citations

Influence of neutrophil depletion on myocardial function and flow after reversible ischemia

1989 • 68 citations

Acute myocardial ischemia: role of atherosclerosis, thrombosis, platelet activation, coronary vasospasm, and altered arachidonic acid metabolism.

1987 • 66 citations

Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation

1986 • 65 citations

Determinants of arrhythmic death due to coronary spasm: effect of preexisting coronary artery stenosis on the incidence of reperfusion arrhythmia.

1982 • 65 citations

Effect of leukotrienes, bradykinin and calcium ionophore (A 23187) on bovine endothelial cells: Release of prostacyclin

1986 • 61 citations

Effects of verapamil on platelet aggregation, ATP release and thromboxane generation

1983 • 58 citations

Myocardial Salvage Induced by REV-5901

1987 • 57 citations

Inhibition of human platelet aggregation and cytoplasmic calcium response by calcium antagonists: studies with aequorin and quin2.

1986 • 54 citations

The effect of aspirin inhibition of PGI2 production on platelet adherence to normal and damaged rabbit aortae

1980 • 53 citations

The pathogenesis and prevention of aortocoronary vein bypass graft occlusion and restenosis after arterial angioplasty: Role of vascular injury and platelet thrombus deposition

1986 • 49 citations

Thromboxane release in coronary artery disease: Spontaneous versus pacing-induced angina

1984 • 47 citations

Roles of Endogenous Prostacyclin and Thromboxane A2 in the Ischemic Canine Heart

1982 • 46 citations

Free radical scavengers improve functional recovery of stunned myocardium in a model of surgical coronary revascularization.

1987 • 43 citations

Differences in polymorphonuclear leukocyte aggregating responses among several species in response to chemotactic stimulation.

1980 • 43 citations

Comparison of the antithrombotic action of calcium antagonist drugs with dipyridamole in dogs

1983 • 42 citations

In vitro effect of the coronary vasodilator diltiazem on human and rabbit platelets

1978 • 41 citations

Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease.

1982 • 39 citations

Superoxide Dismutase Decreases Reperfusion Arrhythmias and Preserves Myocardial Function During Thrombolysis with Tissue Plasminogen Activator

1990 • 37 citations

Effect of metoprolol and propranolol on platelet aggregation and cAMP level in hypertensive patients

1986 • 37 citations

The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes

1984 • 37 citations

Platelet function studies in coronary artery disease. VII. Effect of aspirin and tachycardia stress on aortic and coronary venous blood

1980 • 37 citations

Reduction in myocardial neutrophil accumulation and infarct size following administration of thromboxane inhibitor U-63,557A

1987 • 36 citations

Calcium Blocker Diltiazem Inhibits Platelet Activation and Stimulates Vascular Prostacyclin Synthesis

1986 • 36 citations

Protection of Ischemic Cat Myocardium By CGS-13080, a Selective Potent Thromboxane A2 Synthesis Inhibitor

1983 • 35 citations

Verapamil impairs human neutrophil chemotaxis by a non-calcium-mediated mechanism.

1986 • 34 citations

Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction

1985 • 33 citations

Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides.

1985 • 33 citations

Degradation of cross-linked fibrin by human leukocyte proteases.

1986 • 33 citations

Influence of Drugs that Block Calcium Channels on the Microbicidal Function of Human Neutrophils

1985 • 29 citations

Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1981 • 28 citations

Modulation of vascular tone by neutrophils: dependence on endothelial integrity

1989 • 28 citations

Thrombosis in unstable angina: pathologic aspects.

1987 • 28 citations

Platelets and Prostaglandins in Cardiovascular Disease.

1982 • 26 citations

Reduced Myocardial Neutrophil Accumulation and Infarct Size Following Thromboxane Synthetase Inhibitor or Receptor Antagonist

1989 • 25 citations

Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function

1988 • 25 citations

Significance of prostaglandins and thromboxane A2 for the mode of action of cardiovascular drugs.

1980 • 22 citations

Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina.

1985 • 21 citations

Leukotriene D4 potentiates the contractile effects of epinephrine and norepinephrine on rat aortic rings.

1988 • 20 citations

Inhibition of tissue plasminogen activator activity by aspirin in vivo and its relationship to levels of tissue plasminogen activator inhibitor antigen, plasminogen activator and their complexes

1989 • 20 citations

Modulation of human neutrophil superoxide production by selective thromboxane synthetase inhibitor U63, 557A

1988 • 19 citations

The beneficial effects of nafazatrom (BAYg6575) on experimental coronary thrombosis

1984 • 18 citations

Enhancement of human neutrophil function by platelets: effects of indomethacin

1988 • 18 citations

Endothelium-dependent relaxation of rat aortic rings by leukotriene D4: importance of the magnitude of preload.

1989 • 16 citations

Interference of the calcium antagonists verapamil and nifedipine with lysosomal enzyme release from rabbit polymorphonuclear leukocytes.

1982 • 15 citations

Beta-adrenergic blockade: augmentation of neutrophil-mediated inflammation.

1987 • 14 citations

Hypertension, antihypertensive drugs, and atherogenesis. Mechanisms and clinical implications.

1986 • 13 citations

EFFECT OF ANTIPLATELET THERAPY ON EARLY GRAFT PATENCY AFTER CORONARY ARTERY BYPASS GRAFTING: VA COOPERATIVE STUDY # 207

1987 • 13 citations

Aspirin in myocardial ischemia: Why, when, and how much?

1989 • 13 citations

Effects of peripheral vasodilation caused by Verapamil, nifedipine, and nitroglycerin on plasma prostaglandins and thromboxane concentrations.

1982 • 12 citations

Cytochalasin B facilitates the inhibition of human polymorphonuclear leukocyte generation of superoxide by verapamil.

1984 • 12 citations

Concurrent increases in resistance and transport after coronary obstruction in dogs

1981 • 12 citations

Reduction of the vein graft occlusion rate after coronary artery bypass surgery by treatment with a thromboxane receptor antagonist.

1989 • 7 citations

Relaxation of human internal mammary artery rings by neutrophils: Evidence for generation of an EDRF-like compound

1990 • 1 citations