Cachectin/TNF: A Macrophage Protein That Induces Cachexia and Shock

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

BONE-MARROW TRANSPLANTATION IN A PATIENT WITH THE WISKOTT-ALDRICH SYNDROME

1968 • 873 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Combined Hormonal Infusion Simulates the Metabolic Response to Injury

1984 • 448 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.

1987 • 400 citations

Antiviral effects of recombinant tumour necrosis factor in vitro

1986 • 392 citations

Serum Lipids in Infection

1969 • 371 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor.

1986 • 293 citations

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.

1986 • 280 citations

Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair

1986 • 279 citations

Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal

1980 • 260 citations

The Acute Metabolic Effects of Tumor Necrosis Factor Administration in Humans

1987 • 236 citations

Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes.

1987 • 229 citations

Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.

1987 • 206 citations

The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats

1986 • 203 citations

Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.

1986 • 172 citations

Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

1987 • 135 citations

A Protein from Polymorphonuclear Leukocytes (LEM) Which Affects the Rate of Hepatic Amino Acid Transport and Synthesis of Acute-Phase Globulins

1975 • 128 citations

Control of food intake in cancer cachexia: A challenge and a tool

1976 • 118 citations

Protein Metabolism and Injury

1983 • 116 citations

Hypertriglyceridemia Produced by Endotoxin: Role of Impaired Triglyceride Disposal Mechanisms

1976 • 111 citations

Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.

1988 • 107 citations

Hyperlipidemia, fatty liver, and bromsulfo-phthalein retention in rabbits injected intravenously with bacterial endotoxins

1964 • 106 citations

Modulation of endogenous hormone action by recombinant human tumor necrosis factor.

1987 • 103 citations

Infection with Diplococcus pneumoniae and Salmonella typhimurium in Monkeys: Changes in Plasma Lipids and Lipoproteins

1972 • 89 citations

Tumor necrosis factor receptors in HeLa cells and their regulation by interferon-gamma.

1986 • 86 citations

THE ANOREXIA‐CACHEXIA SYNDROME: A NEW HYPOTHESIS

1974 • 85 citations

Cachectin: Its Impact on Metabolism and Nutritional Status

1988 • 64 citations

Defective lipid disposal mechanisms during bacterial infection in rhesus monkeys

1976 • 63 citations

Lectin-gold labeling of glycoconjugates in normal and Brattleboro rat papilla: effect of vasopressin

1988 • 62 citations

Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells

1984 • 52 citations

Membrane Defect and Energy Status of Rabbit Skeletal Muscle Cells in Sepsis and Septic Shock

1981 • 41 citations

Endotoxin-Induced Alterations in Isolated Fat Cells: Effect on Norepinephrine-Stimulated Lipolysis and Cyclic 3',5'-Adenosine Monophosphate Accumulation

1974 • 21 citations

Effect of daily submaximal exercise on cellular membrane function during intravenous refeeding in normal man

1987 • 1 citations