Endothelial cell biology in relation to current concepts of vessel wall structure and function.

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

1990 • 1,012 citations

Haemodynamic shear stress activates a K+ current in vascular endothelial cells

1988 • 1,003 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

1986 • 835 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

1987 • 703 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate

1989 • 652 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Molecular biology and biochemistry of the endothelins

1989 • 620 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

1989 • 612 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Elevated plasma endothelin in patients with diabetes mellitus

1990 • 492 citations

The discovery of nitric oxide as the endogenous nitrovasodilator.

1988 • 486 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

1989 • 420 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium

1990 • 400 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

1990 • 390 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

1989 • 349 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

1989 • 346 citations

Fibroblast growth factor: Structural and biological properties

1987 • 334 citations

Mediators produced by the endothelial cell.

1988 • 329 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells

1989 • 285 citations

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.

1986 • 283 citations

Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

1986 • 283 citations

Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries.

1990 • 282 citations

Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs

1988 • 279 citations

Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

1977 • 279 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.

1990 • 271 citations

Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.

1988 • 269 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells

1990 • 259 citations

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B₄

1989 • 244 citations

Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells

1988 • 241 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Endothelium-dependent vascular responses. Mediators and mechanisms.

1989 • 239 citations

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

1989 • 238 citations

Endothelin: a potent renal and systemic vasoconstrictor peptide

1989 • 232 citations

Expression of the potent vasoconstrictor endothelin in the human central nervous system.

1990 • 228 citations

ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE?

1988 • 214 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Some electrical properties of the endothelium‐dependent hyperpolarization recorded from rat arterial smooth muscle cells.

1989 • 209 citations

Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells

1990 • 196 citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

1990 • 187 citations

Structural Organization and Chromosomal Assignment of the Gene Encoding Endothelin

1989 • 178 citations

Endothelin mediates the renal vasoconstriction induced by cyclosporine in the rat.

1990 • 176 citations

Endothelin Stimulation of Cytosolic Calcium and Gonadotropin Secretion in Anterior Pituitary Cells

1990 • 172 citations

Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.

1990 • 170 citations

Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.

1986 • 169 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

The Human Preproendothelin-1 Gene

1989 • 166 citations

Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators

1989 • 166 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Endothelin inhibits renin release from isolated rat glomeruli

1988 • 165 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Effects of cytokines on vascular endothelium: Their role in vascular and immune injury

1989 • 161 citations

Heterogeneity of cell surface endothelin receptors.

1990 • 159 citations

Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.

1990 • 149 citations

Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain

1989 • 142 citations

Endothelium‐derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells

1988 • 130 citations

Endothelin has potent inotropic effects in rat atria

1988 • 127 citations

Effects of endothelin in the systemic and renal vascular beds in vivo

1988 • 125 citations

Blood-tissue exchange via transport and transformation by capillary endothelial cells.

1989 • 125 citations

Endothelin produces pulmonary vasoconstriction and systemic vasodilation

1989 • 124 citations

Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.

1984 • 122 citations

Localization of endothelin receptors in rat kidney

1989 • 120 citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

1989 • 116 citations

Immunoreactive endothelin in rat kidney inner medulla: Marked decrease in spontaneously hypertensive rats

1989 • 115 citations

Endothelin: A new inhibitor of renin release

1988 • 105 citations

Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

1990 • 104 citations

Functions of the Endothelial Cell Surface

1986 • 104 citations

Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock

1989 • 102 citations

Bradykinin stimulates the production of cyclic GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells.

1990 • 101 citations

Synthesis of the vasoconstrictor peptide endothelin in kidney cells

1989 • 99 citations

Endothelin induces potent microvascular constriction

1988 • 98 citations

Glomerular endothelial cells respond to calcium-mobilizing agonists with release of EDRF

1990 • 98 citations

Characterization of Endothelin-1 Stimulation of Catecholamine Release from Adrenal Chromaffin Cells

1989 • 93 citations

Endothelial communication. State of the art lecture.

1988 • 91 citations

Does Endothelium-Derived Nitric Oxide Have a Rolein Cytokine-Induced Hypotension?

1990 • 89 citations

Leukotriene C promotes prostacyclin synthesis by human endothelial cells.

1983 • 89 citations

Production of Endothelin 1 by Cultured Bovine Retinal Endothelial Cells and Presence of Endothelin Receptors on Associated Pericytes

1989 • 88 citations

The vascular endothelium: a survey of some newly evolving biochemical and physiological features

1985 • 88 citations

Influence of endothelin on piglet cerebral microcirculation

1989 • 86 citations

Nature of Thrombin-induced Sustained Increase in Cytosolic Calcium Concentration in Cultured Endothelial Cells

1989 • 85 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Endothelin messenger RNA and receptors are differentially expressed in cultured human breast epithelial and stromal cells.

1990 • 81 citations

Endothelin sensitivity and receptor binding in the aorta of spontaneously hypertensive rats

1989 • 79 citations

Secretion of endothelin and related peptides from renal epithelial cell lines

1989 • 79 citations

Identification and characterization of endothelin binding sites in rat renal papillary and glomerular membranes

1989 • 78 citations

Going with the flow

1988 • 78 citations

Effects of endothelin on coronary flow, mechanical performance, oxygen uptake, and formation of purines and on outflow of prostacyclin in the isolated rabbit heart.

1990 • 76 citations

Endothelin Stimulates Basal and Stretch-Induced Atrial Natriuretic Peptide Secretion from the Perfused Rat Heart*

1990 • 71 citations

Prostaglandins, other eicosanoids and endothelial cells

1985 • 63 citations

Roles of calcium, cyclic nucleotides, and protein kinase C in regulation of endothelial permeability.

1990 • 63 citations

Metabolic interactions between eicosanoids in blood and vascular cells

1989 • 56 citations

Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in an in vitro model.

1989 • 56 citations

Calcium dependence of phenylephrine-, endothelin-, and potassium chloride-stimulated atrial natriuretic factor secretion from long term primary neonatal rat atrial cardiocytes.

1990 • 51 citations

Endothelium and asymmetrical responses of the coronary arterial wall

1984 • 50 citations

Mechanical stimulation induces Ca²⁺_i transients and membrane depolarization in cultured endothelial cells Effects on Ca²⁺_i in co‐perfused smooth muscle cells

1988 • 46 citations

L-Citrulline Production from L-Arginine by Macrophage Nitric Oxide Synthase

1990 • 45 citations

The Hemodynamic Effects of Endothelin-1 in the Pithed Rat

1989 • 42 citations

Polymorphonuclear leukocytes induced vasoconstriction in isolated canine coronary arteries.

1990 • 42 citations

Endothelial Cell Metabolism of Biogenic Amines

1986 • 25 citations

Glomerular filtration dynamics during renal vasodilation with acetylcholine in the dog

1983 • 22 citations

Some structural and functional aspects of endothelial cells

1985 • 13 citations

Angiogenesis InVitro: Morphogenetic and Invasive Properties of Endothelial Cells

1990 • 11 citations

Interaction of platelets with endothelial cells: Activation of a novel neutral protease

1989 • 11 citations

Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides

1990 • 7 citations

Some electrical properties of the endothelium-dependent hyperpolarization recorded from rat arterial smooth muscle cells

1989 • 1 citations