Prostaglandins, Cyclo-oxygenase Inhibitors, and Thromboxane Synthetase Inhibitors in the Pathogenesis of Multiple Systems Organ Failure

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome

1983 • 654 citations

LOW-DOSE ASPIRIN PREVENTS PREGNANCY-INDUCED HYPERTENSION AND PRE-ECLAMPSIA IN ANGIOTENSIN-SENSITIVE PRIMIGRAVIDAE

1986 • 544 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles

1972 • 241 citations

Overview of physiological and pathophysiological effects of thromboxane A2.

1987 • 226 citations

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man

1982 • 208 citations

Thromboxane A2 Mediates Augmented Polymorphonuclear Leukocyte Adhesiveness

1980 • 205 citations

Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance

1982 • 197 citations

Prostaglandins, their intermediates and precursors: Cardiovascular actions and regulatory roles in normal and abnormal circulatory systems

1979 • 188 citations

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

1983 • 183 citations

Inhibition of Cyclo-oxygenase Attenuates the Metabolic Response to Endotoxin in Humans

1988 • 171 citations

PLASMA THROMBOXANE CONCENTRATIONS ARE RAISED IN PATIENTS DYING WITH SEPTIC SHOCK

1982 • 160 citations

Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium

1978 • 157 citations

Role of Thromboxane and Prostacyclin in Pulmonary Vasomotor Changes after Endotoxin in Dogs

1981 • 151 citations

Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2

1978 • 145 citations

Eicosanoids and lung inflammation.

1987 • 136 citations

Ibuprofen in canine endotoxin shock.

1982 • 131 citations

The biochemical pharmacology of thromboxane synthase inhibition in man.

1985 • 122 citations

PHARMACOLOGICAL INTERACTIONS BETWEEN PROSTACYCLIN AND THROMBOXANES

1983 • 117 citations

Regulation of the Arachidonic Acid Cascade

1977 • 115 citations

Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep.

1982 • 107 citations

URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION

1981 • 99 citations

Thromboxane A2 biosynthesis in human disease.

1987 • 95 citations

Thromboxane A2 mediates lung vasoconstriction but not permeability after endotoxin.

1983 • 87 citations

Pulmonary hypertension correlated to pulmonary thromboxane synthesis.

1980 • 83 citations

Elevated plasma 6-keto-prostaglandin F1α in patients in septic shock

1985 • 78 citations

The effect of prostacyclin infusion on endotoxin-induced lung injury.

1981 • 77 citations

Analgesic‐antipyretic drugs as antagonists of endotoxin shock in dogs

1962 • 77 citations

Treatment of pulmonary embolism with prostacyclin.

1980 • 75 citations

Pharmacological studies in inflammation due to exposure to ultraviolet radiation

1970 • 62 citations

A pharmacological approach to thromboxane receptor antagonism.

1987 • 55 citations

Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion

1982 • 50 citations

The clinical significance of prostaglandins and thromboxane as mediators of septic shock

1987 • 47 citations

Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep.

1985 • 45 citations

Improvement in Organ Blood Flow by Inhibition of Thromboxane Synthetase During Experimental Endotoxic Shock in the Rat

1986 • 41 citations

The role of prostaglandins in sepsis.

1982 • 39 citations

The effects of a prostaglandin synthetase inhibitor, ibuprofen, on the cardiopulmonary response to endotoxin in sheep.

1982 • 38 citations

Do prostacyclin and thromboxane play a role in endotoxic shock?

1981 • 38 citations

Cardiovascular and pulmonary effects of thromboxane B2 in the dog.

1979 • 37 citations

Indomethacin treatment following baboon endotoxin shock improves survival.

1980 • 36 citations

6-keto PGE1: a possible metabolite of prostacyclin having platelet antiaggregatory effects.

1980 • 33 citations

Prostacyclin and thromboxane A2 in septic shock: species differences.

1986 • 29 citations

Pharmacology of thromboxane synthetase inhibitors.

1987 • 29 citations

In vivo AND in vitro EFFECTS OF ENDOTOXIN ON PROSTAGLANDIN RELEASE FROM RAT LUNG

1981 • 28 citations

Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046.

1986 • 28 citations

Comparative effects of endoperoxide PGH2 and an analog on the pulmonary vascular bed

1977 • 26 citations

Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.

1984 • 23 citations

Prostaglandins in shock: to give or to block?

1980 • 22 citations

Increased survival of endotoxin-injected dogs treated with methylprednisolone, naloxone, and ibuprofen.

1984 • 21 citations

Implications for thromboxane A2 in the pathogenesis of endotoxic shock.

1981 • 21 citations

Prostaglandin E1 and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury

1982 • 21 citations

Endotoxic shock in the primate: Effects of aspirin and dipyridamole administration

1981 • 21 citations

Effects of oleic acid on pulmonary capillary leak and thromboxanes

1984 • 19 citations

Thromboxane A2 in health and disease.

1987 • 16 citations

Blockade of Thromboxane and the Prevention of Eicosanoid-Induced Sudden Death in Mice

1985 • 14 citations

Escherichia coli-induced lung and liver dysfunction in dogs: effects of flunixin meglumine treatment.

1987 • 14 citations

Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock.

1985 • 13 citations

The role of thromboxane in primate endotoxin shock

1985 • 12 citations

The effect of ibuprofen on endotoxin-induced injury in sheep

1986 • 11 citations

Methylprednisolone plus ibuprofen increases mortality in septic rats.

1984 • 11 citations

Increased survival in bacteremic sheep treated with ibuprofen

1986 • 9 citations

Streptococcus pneumoniae-Induced Alterations in Levels of Circulating Thromboxane and Prostacyclin: Dissociation from Granulocytopenia, Thrombocytopenia, and Pulmonary Leukostasis

1986 • 8 citations