Macrophage NRAMP1 and its role in resistance to microbial infections

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Inactivation of Antibiotics and the Dissemination of Resistance Genes

1994 • 1,766 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

1998 • 736 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

The contribution of H LA to rheumatoid arthritis

1989 • 386 citations

Genetic regulation of resistance to intracellular pathogens

1982 • 382 citations

Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.

1981 • 343 citations

A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

1996 • 330 citations

Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells.

1993 • 309 citations

Identification and characterization of a second mouse Nramp gene

1995 • 289 citations

Susceptibility to Leprosy Is Linked to the HumanNRAMP1Gene

1998 • 266 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro.

1983 • 257 citations

Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors.

1995 • 256 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

Infectious Disease Surveillance: a Crumbling Foundation

1994 • 180 citations

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.

1995 • 174 citations

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele

1996 • 163 citations

Structural conservation of ion conduction pathways in K channels and glutamate receptors.

1995 • 158 citations

Genetic Control of Natural Resistance to Infection and Malignancy

1980 • 156 citations

Genomic Organization and Sequence of the Human NRAMP Gene: Identification and Mapping of a Promoter Region Polymorphism

1995 • 149 citations

Expression of the natural resistance gene Lsh in resident liver macrophages

1984 • 146 citations

Genetics and Resistance to Tuberculosis

1992 • 139 citations

Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG).

1984 • 128 citations

Resistance to intracellular infections: comparative genomic analysis of Nramp

1996 • 128 citations

Functional Complementation of the Yeast Divalent Cation Transporter Family SMF by NRAMP2, a Member of the Mammalian Natural Resistance-associated Macrophage Protein Family

1997 • 116 citations

Cloning and characterization of a second human NRAMP gene on chromosome 12q13

1995 • 114 citations

Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice

1993 • 112 citations

Topology of the hydrophobic membrane-bound components of the histidine periplasmic permease. Comparison with other members of the family.

1992 • 110 citations

Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

1997 • 104 citations

THE CHANGING FACE OF TUBERCULOSIS

1995 • 101 citations

PROSPECTS FOR NEW INTERVENTIONS IN THE TREATMENT AND PREVENTION OF MYCOBACTERIAL DISEASE

1995 • 91 citations

Chapter 11 Cytomegalovirus Plasmid Vectors for Permanent Lines of Polarized Epithelial Cells

1994 • 90 citations

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.

1996 • 90 citations

Immunogenetics in the analysis of resistance to intracellular pathogens

1995 • 75 citations

Genetic and Physical Mapping of 2q35 in the Region of the NRAMP and IL8R Genes: Identification of a Polymorphic Repeat in Exon 2 of NRAMP

1994 • 57 citations

An RFLP map for 2q33‐q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy

1993 • 53 citations

Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice

1986 • 51 citations

Killing of Mycobacterium smegmatis by Macrophages From Genetically Susceptible and Resistant Mice

1990 • 49 citations

Epistatic modeling in rheumatoid arthritis: An application of the Risch theory

1993 • 46 citations

Macrophage-Listeria interactions.

1994 • 38 citations

Genetics of Leprosy

1991 • 29 citations

No evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia.

1997 • 29 citations

Identification of C to T mutation at position −236 bp in the humanNRAMP1 gene promoter

1996 • 25 citations

Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis.

1997 • 24 citations

Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2.

1994 • 22 citations

Linkage and association studies of the natural resistance associated macrophage protein 1 (NRAMP1) locus in rheumatoid arthritis.

1997 • 22 citations