Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

ACTIN AND ACTIN-BINDING PROTEINS. A CRITICAL EVALUATION OF MECHANISMS AND FUNCTIONS

1986 • 1,493 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

[46] Fibronectin: Purification, immunochemical properties, and biological activities

1982 • 542 citations

Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice

1988 • 453 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets : procedure and some applications. 1979 [classical article]

1992 • 453 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

1997 • 386 citations

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.

1996 • 365 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

2000 • 326 citations

Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation

1999 • 318 citations

Sequence and domain structure of talin

1990 • 314 citations

Integrin-mediated Adhesion Regulates Cell Polarity and Membrane Protrusion through the Rho Family of GTPases

2001 • 280 citations

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1987 • 274 citations

Calpain Regulates Actin Remodeling during Cell Spreading

1998 • 264 citations

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

1998 • 260 citations

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin

1999 • 249 citations

Disruption of the Mouse μ-Calpain Gene Reveals an Essential Role in Platelet Function

2001 • 237 citations

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

1994 • 219 citations

Casein Zymography: A Method to Study μ-Calpain, M-Calpain, and Their Inhibitory Agents

1995 • 214 citations

Calpains Are Activated in Necrotic Fibers from mdx Dystrophic Mice

1995 • 211 citations

Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells.

1990 • 203 citations

Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity

1998 • 192 citations

Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

1994 • 183 citations

Disruption of the Talin Gene Compromises Focal Adhesion Assembly in Undifferentiated but Not Differentiated Embryonic Stem Cells

1998 • 182 citations

Procaspase-3 and Poly(ADP)ribose Polymerase (PARP) Are Calpain Substrates

1999 • 180 citations

Dicistronic transcription units for gene expression in mammalian cells

1993 • 179 citations

Implication of calpain in caspase activation during B cell clonal deletion

1999 • 178 citations

Ip-10 Inhibits Epidermal Growth Factor–Induced Motility by Decreasing Epidermal Growth Factor Receptor–Mediated Calpain Activity

1999 • 140 citations

Direct interactions between talin and actin

1990 • 131 citations

Calmodulin and calcium-dependent protease I coordinately regulate the interaction of fodrin with actin.

1990 • 131 citations

Cleavage of Focal Adhesion Kinase by Different Proteases during Src-regulated Transformation and Apoptosis

2001 • 131 citations

Calpain Mediates Integrin-induced Signaling at a Point Upstream of Rho Family Members

1999 • 124 citations

Identification of talin as a major cytoplasmic protein implicated in platelet activation

1985 • 121 citations

Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active

2000 • 102 citations

Calpain : pharmacology and toxicology of calcium-dependent protease

1999 • 97 citations

Studies on proteins that co-purify with smooth muscle vinculin: identification of immunologically related species in focal adhesions of nonmuscle and Z-lines of muscle cells.

1986 • 79 citations

An antisense oligodeoxyribonucleotide to m-calpain mRNA inhibits myoblast fusion

1995 • 71 citations

Potential m-Calpain Substrates during Myoblast Fusion

1999 • 67 citations

The Behavior of Calpain-Generated N- and C-Terminal Fragments of Talin in Integrin-Mediated Signaling Pathways

1999 • 59 citations

Calpain Zymography with Casein or Fluorescein Isothiocyanate Casein

2003 • 55 citations

Unphosphorylated and tyrosine‐phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: Implications for the possible involvement of calpain II in mitosis‐specific degradation of paxillin

1994 • 49 citations

Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40.

1997 • 34 citations

Intracellular Processing of Talin Occurs within Focal Adhesions

1995 • 31 citations

Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor.

1993 • 26 citations

Constitutive expression of calpain II in the rat uterus during pregnancy and involution

1991 • 24 citations