MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Paxillin and focal adhesion signalling

2000 • 765 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

The calpain family and human disease

2001 • 465 citations

Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.

1989 • 416 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

1997 • 386 citations

Cutting to the chase: calpain proteases in cell motility

2002 • 386 citations

Focal adhesions: Structure and dynamics

2000 • 380 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

2000 • 336 citations

Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

2000 • 326 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

v-SRC'S hold over actin and cell adhesions

2002 • 304 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

Anchorage-dependent ERK signaling – mechanisms and consequences

2002 • 287 citations

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1987 • 274 citations

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

1996 • 274 citations

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway

2000 • 272 citations

Calpain Regulates Actin Remodeling during Cell Spreading

1998 • 264 citations

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

1998 • 260 citations

Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

2001 • 250 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

1998 • 236 citations

Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling

2001 • 210 citations

Calpain and caspase: can you tell the difference?, by Kevin K.W. Wang

2000 • 190 citations

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

1996 • 167 citations

Biophysical Integration of Effects of Epidermal Growth Factor and Fibronectin on Fibroblast Migration

1999 • 155 citations

Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading

2002 • 144 citations

The TAO of MEKK

1998 • 132 citations

MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton

1999 • 125 citations

Calpain cleavage of integrin β cytoplasmic domains

1999 • 115 citations

Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active

2000 • 102 citations

MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

1999 • 93 citations

The Bovine Papillomavirus E6 Protein Binds to the LD Motif Repeats of Paxillin and Blocks Its Interaction with Vinculin and the Focal Adhesion Kinase

1997 • 91 citations

Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes

2002 • 52 citations

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression

2003 • 38 citations