Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase

THE UBIQUITIN SYSTEM

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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

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1999 • 663 citations

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2000 • 574 citations

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

1995 • 556 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

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2000 • 394 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

The hPLIC Proteins May Provide a Link between the Ubiquitination Machinery and the Proteasome

2000 • 348 citations

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

2000 • 334 citations

Nuclear bodies: multifaceted subdomains of the interchromatin space

1999 • 330 citations

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

2000 • 321 citations

Ubiquitin and its kin: how close are the family ties?

2000 • 316 citations

Monoubiquitin carries a novel internalization signal that is appended to activated receptors

2000 • 291 citations

Ubiquitin is part of the retrovirus budding machinery

2000 • 288 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function.

1991 • 212 citations

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1999 • 199 citations

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: The proline glycine and methionine-rich motif

1998 • 157 citations

The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase

1999 • 154 citations

Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

2000 • 147 citations

Ubiquitination of HIV-1 and MuLV Gag

2000 • 139 citations

The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP

2000 • 135 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 106 citations

mGrb10 Interacts with Nedd4

1999 • 105 citations

Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases

1997 • 86 citations

A Single Point Mutation in a Group I WW Domain Shifts Its Specificity to That of Group II WW Domains

1999 • 67 citations

Nuclear Import/Export of hRPF1/Nedd4 Regulates the Ubiquitin- dependent Degradation of Its Nuclear Substrates

2001 • 51 citations

Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF

2001 • 50 citations

Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI

2001 • 15 citations

Analysis of Nedd4 expression during skeletal development in the mouse limb

2000 • 13 citations