Cellular and Molecular Actions of Lamotrigine: Possible Mechanisms of Efficacy in Bipolar Disorder

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons

1997 • 1,415 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

1994 • 829 citations

A summary of mechanistic hypotheses of gabapentin pharmacology

1998 • 778 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

1993 • 635 citations

Cerebral Metabolic Rates for Glucose in Mood Disorders

1985 • 595 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Mechanism of anticonvulsant action of valproate

1982 • 344 citations

Stress, depression and the mesolimbic dopamine system

1996 • 318 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Slow Recovery from Inactivation of Na⁺Channels Underlies the Activity-Dependent Attenuation of Dendritic Action Potentials in Hippocampal CA1 Pyramidal Neurons

1997 • 269 citations

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1995 • 255 citations

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

1993 • 254 citations

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

1989 • 225 citations

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

1991 • 222 citations

Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?

1998 • 208 citations

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

1996 • 204 citations

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

1994 • 201 citations

Lamotrigine

1992 • 184 citations

Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells.

1993 • 179 citations

Spectrum of Activity of Lamotrigine in Treatment-Refractory Bipolar Disorder

1999 • 170 citations

A Review of Functional Neuroimaging in Mood Disorders: Positron Emission Tomography and Depression

1997 • 166 citations

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

1994 • 165 citations

The Anticonvulsant Lamotrigine in Treatment-Resistant Manic-Depressive Illness

1997 • 159 citations

Characterization of lamotrigine inhibition of Na⁺ channels in rat hippocampal neurones

1997 • 148 citations

Mechanisms of Action of Currently Prescribed and Newly Developed Antiepileptic Drugs

1994 • 141 citations

Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats

1998 • 128 citations

Clinical Pharmacology of Lamotrigine

1991 • 126 citations

Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

1996 • 122 citations

Lamotrigine in Rapid-Cycling Bipolar Disorder

1997 • 120 citations

Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin

1997 • 120 citations

Mechanisms of Action of Anticonvulsants in Affective Disorders

1992 • 119 citations

An open study of lamotrigine in refractory bipolar depression

1997 • 118 citations

Functional Properties of Rat Brain Sodium Channels Expressed in a Somatic Cell Line

1990 • 104 citations

Uptake of ^99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: Associations with mania

1997 • 98 citations

Sodium Valproate Increases Potassium Conductance in Aplysia Neurons

1978 • 90 citations

A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder.

1997 • 90 citations

Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture

1994 • 86 citations

Acute Treatment of Bipolar Depression with Gabapentin

1997 • 85 citations

Addition of Lamotrigine to Valproate May Enhance Efficacy in the Treatment of Bipolar Affective Disorder

1996 • 81 citations

Seizure Severity and the Quality of Life

1993 • 79 citations

Preferential Interaction of ω-Conotoxins with Inactivated N-type Ca²⁺Channels

1997 • 75 citations

Lamotrigine Treatment of Refractory Bipolar Disorder

1997 • 70 citations

Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture

1990 • 69 citations

Steady-state availability of sodium channels. Interactions between activation and slow inactivation

1992 • 69 citations

Lamotrigine Reduces Voltage‐Gated Sodium Currents in Rat Central Neurons in Culture

1997 • 66 citations

Regulation of signal transduction pathways by mood-stabilizing agents: implications for the delayed onset of therapeutic efficacy.

1996 • 66 citations

Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neurons

1996 • 61 citations

A calcium antagonistic effect of the new antiepileptic drug lamotrigine

1997 • 58 citations

Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine

1990 • 57 citations

Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

1998 • 45 citations

Molecular properties of a superfamily of plasma-membrane cation channels

1994 • 45 citations

GENETICS OF MANIC DEPRESSIVE ILLNESS

1997 • 45 citations

State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

1996 • 44 citations

Effects of valproate on early and late potassium currents of single neurons

1993 • 41 citations

Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus

1997 • 40 citations

The effect of lamotrigine upon development of cortical kindled seizures in the rat

1991 • 39 citations

A field potential analysis on the effects of lamotrigine, GP 47779, and felbamate in neocortical slices

1996 • 38 citations

Potent block of potassium currents in rat isolated sympathetic neurones by the uncharged form of amitriptyline and related tricyclic compounds

1995 • 24 citations

Forskolin and 3‐Isobutyl‐l‐Methylxanthine Increase Basal and Sodium Nitroprusside‐Elevated Cyclic GMP Levels in Adult Guinea‐Pig Cerebellar Slices

1994 • 18 citations

Lamotrigine inhibits tetraethylammonium-induced synaptic plasticity in the rat amygdala

1997 • 14 citations

Organic Mania Induced by Phenytoin: A Case Report^*

1989 • 13 citations

Lamotrigine in treatment refractory manic depression

1996 • 13 citations

Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neurons

1996 • 7 citations

Molecular Genetics of Bipolar Disorder

1996 • 7 citations