State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

1992 • 656 citations

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1994 • 630 citations

Antiepileptic Drug Mechanisms of Action

1995 • 575 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1989 • 467 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase

1993 • 270 citations

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1995 • 255 citations

Na+ channels as targets for neuroprotective drugs

1995 • 255 citations

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

1991 • 222 citations

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

1991 • 219 citations

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

1993 • 180 citations

Na+ currents that fail to inactivate

1993 • 160 citations

Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats

1995 • 148 citations

Downregulation of sodium channels during anoxia: a putative survival strategy of turtle brain

1992 • 142 citations

Neurochemical and Behavioral Aspects of Lamotrigine

1991 • 142 citations

Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells.

1984 • 133 citations

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

1993 • 118 citations

Antiepileptic Drug Mechanisms of Action

1993 • 110 citations

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87

1992 • 107 citations

Functional Properties of Rat Brain Sodium Channels Expressed in a Somatic Cell Line

1990 • 104 citations

Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.

1994 • 102 citations

Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion.

1994 • 81 citations

Steady-state availability of sodium channels. Interactions between activation and slow inactivation

1992 • 69 citations

Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat

1993 • 56 citations

The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study

1993 • 55 citations

Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats

1994 • 31 citations

Role of angiotensin receptor subtypes in the response of rabbit brain arterioles to angiotensin.

1994 • 30 citations

Molecular Mechanisms of Inactivation and Modulation of Sodium Channels

1994 • 14 citations

The pyrimidine derivative BW 1003C87 protects against excitotoxic lesions induced by kainate in the rat striatum

1994 • 5 citations

Deleted Work

1955 • 0 citations