Mechanism of anticonvulsant action of valproate

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1981 • 1,044 citations

GABA‐Benzodiazepine‐Barbiturate Receptor Interactions

1981 • 910 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Advances in epileptology

1990 • 543 citations

Antiepileptic drugs : mechanisms of action

1980 • 508 citations

Epilepsy and γ-Aminobutyric Acid-Mediated Inhibition

1975 • 491 citations

EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM¹

1969 • 394 citations

A rapid method for preparing synaptosomes: Comparison, with alternative procedures

1981 • 392 citations

Neurotransmitters, seizures and epilepsy

1982 • 353 citations

Clinical Pharmacokinetics of Valproic Acid1

1980 • 334 citations

‘Wet-Dog’ shake behaviour in the rat: A possible quantitative model of central 5-hydroxytryptamine activity☆

1977 • 330 citations

Sodium Valproate

1977 • 318 citations

GABA and benzodiazepine receptors.

1981 • 289 citations

Effect of sodium n-dipropylacetate on audiogenic seizures and brain γ-aminobutyric acid level

1973 • 285 citations

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

1982 • 258 citations

METABOLISM OF BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES: RESPONSE TO DEPOLARIZING INFLUENCES

1972 • 215 citations

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

1981 • 211 citations

CLINICAL, BIOCHEMICAL, AND PHYSIOLOGICAL FEATURES DISTINGUISHING MYOCLONUS RESPONSIVE TO 5-HYDROXYTRYPTOPHAN, TRYPTOPHAN WITH A MONOAMINE OXIDASE INHIBITOR, AND CLONAZEPAM

1977 • 208 citations

Pharmacokinetics and bioavailability of sodium valproate

1977 • 204 citations

Valproic acid versus ethosuximide in the treatment of absence seizures

1982 • 204 citations

Audiogenic seizure protection by elevated brain GABA concentration in mice: Effects of γ-acetylenic GABA and γ-vinyl GABA, two irreversible GABA-T inhibitors

1977 • 203 citations

Antiepileptic Therapy: Advances in Drug Monitoring

1980 • 201 citations

Treatment of Generalized Epilepsies of Childhood and Adolescence with Sodium Valproate (‘Epilim’)

1977 • 193 citations

Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures

1976 • 175 citations

Seizure Protection and Increased Nerve-Terminal GABA: Delayed Effects of GABA Transaminase Inhibition

1980 • 175 citations

Epilepsy after non-missile head injuries

1976 • 173 citations

Sodium Valproate in Treatment of Epilepsy

1974 • 172 citations

Epilepsy after Non-Missile Head Injuries

1973 • 171 citations

Effect of Inhibitors of GABA Transaminase on the Synthesis, Binding, Uptake and Metabolism of GABA

1980 • 167 citations

Valproic Acid

1980 • 160 citations

Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons

1979 • 160 citations

Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: A common mode of anticonvulsant action

1979 • 159 citations

The distribution of free amino acids in subcellular fractions of guinea-pig brain

1966 • 155 citations

Valproic acid dosage and plasma protein binding and clearance

1980 • 148 citations

DT‐n‐PROPYLACETATE AND GABA DEGRADATION. PREFERENTIAL INHIBITION OF SUCCINIC SEMIALDEHYDE DEHYDROGENASE AND INDIRECT INHIBITION OF GABA‐TRANSAMINASE

1979 • 147 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

Pharmacokinetics of di-n-propylacetate in epileptic patients

1975 • 142 citations

GABA in plasma and cerebrospinal fluid of different species. Effects of ?-acetylenic GABA, ?-vinyl GABA and sodium valproate

1979 • 131 citations

Morphine abstinence is associated with increased brain cyclic AMP

1975 • 130 citations

Biochemical pharmacology of Gabaergic agonists

1979 • 128 citations

Serum protein binding and pharmacokinetics of valproate in man, dog, rat and mouse.

1978 • 128 citations

Valproic Acid

1979 • 126 citations

Valproate induced changes in GABA metabolism at the subcellular level

1981 • 125 citations

Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect.

1979 • 125 citations

Differential ontogeny of Type 1 and Type 2 benzodiazepine receptors

1981 • 122 citations

Disposition of valproic acid in man

1977 • 121 citations

Effect of Sodium Valproate on Tardive Dyskinesia

1976 • 118 citations

GABA and acute psychoses

1982 • 117 citations

Monoamine and GABA metabolism and the anticonvulsant action of DI-n-propylacetate and ethanolamine-O-sulphate

1977 • 113 citations

The inhibitory effect of sodium n‐dipropyl acetate on the degradative enzymes of the GABA shunt

1975 • 112 citations

Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse.

1982 • 111 citations

A Controlled Study of the Effect of Sodium Valproate on Photosensitive Epilepsy and Its Prognosis

1978 • 110 citations

EFFECTS OF THE ANTICONVULSANT SODIUM VALPROATE ON γ‐AMINOBUTYRATE AND ALDEHYDE METABOLISM IN OX BRAIN

1978 • 109 citations

Effect of n‐dipropylacetate on amino acid concentrations in mouse brain: correlations with anti‐convulsant activity

1978 • 108 citations

The Delayed Effect of Sodium Valproate on the Photoconvulsive Response in Man

1979 • 108 citations

MUSCIMOL UPTAKE, RELEASE AND BINDING IN RAT BRAIN SLICES

1978 • 102 citations

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

1978 • 102 citations

Valproic Acid Therapy in Childhood Epilepsy

1980 • 99 citations

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

1981 • 98 citations

Controlled trial of sodium valproate in severe epilepsy.

1975 • 97 citations

Enhancement of GABA binding by pentobarbitone

1980 • 95 citations

Research Progress in Epilepsy

1982 • 95 citations

Sodium Valproate Increases Potassium Conductance in Aplysia Neurons

1978 • 90 citations

Valproate and Clonazepam in the Treatment of Severe Progressive Myoclonus Epilepsy

1982 • 90 citations

Effect of diazepam on fate of intracisternally injected serotonin-C14

1970 • 90 citations

Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat

1981 • 89 citations

PHARMACOKINETICS OF VALPROIC ACID AFTER ORAL AND INTRAVENOUS ADMINISTRATION

1978 • 88 citations

A comparison of phenytoin and valproate in previously untreated adult epileptic patients.

1982 • 87 citations

Concentration of Dipropylacetate in Plasma

1975 • 87 citations

Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio

1975 • 86 citations

STABILITY OF SYNAPTOSOMAL GABA LEVELS AND THEIR USE IN DETERMINING THE IN VIVO EFFECTS OF DRUGS: CONVULSANT AGENTS

1979 • 85 citations

Stuporous Episodes During Treatment with Sodium Valproate: Report of Seven Cases

1982 • 85 citations

The Use of Inhibitors of GABA‐Transaminase for the Determination of GABA Turnover in Mouse Brain Regions: An Evaluation of Aminooxyacetic Acid and Gabaculine

1982 • 85 citations

Acute effects of sodium valproate and ?-vinyl gaba on regional amino acid metabolism in the rat brain: Incorporation of 2-[14C]glucose into amino acids

1982 • 83 citations

Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo

1979 • 83 citations

Transmission of valproic acid (Depakene) across theplacenta: Half-life of the drug in mother and baby

1979 • 81 citations

Photosensitive epilepsy : a review of the literature and a study of 460 patients

1975 • 80 citations

Use of Valproic Acid in Treatment of Infantile Spasms

1982 • 80 citations

Side Effects of Sodium Valproate in Monotherapy Controlled by Plasma Levels: A Study in 88 Pediatric Patients

1982 • 79 citations

THE EFFECT OF SODIUM‐n‐DIPROPYL ACETATE ON γ‐AMINOBUTYRIC ACID‐DEPENDENT INHIBITION IN THE RAT CORTEX AND SUBSTANTIA NIGRA IN RELATION TO ITS ANTICONVULSANT ACTIVITY

1980 • 79 citations

Valproate tremors

1982 • 79 citations

Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.

1980 • 78 citations

Evidence that gaba mechanisms mediate the anxiolytic action of benzodiazepines: A study with valproic acid

1980 • 78 citations

Valproic acid: in vitro plasma protein binding and interaction with phenytoin.

1979 • 78 citations

A Study of the Action of Valproic Acid on the Kindling Effect

1977 • 76 citations

Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content

1983 • 75 citations

Huntington's disease

1976 • 74 citations

Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex

1981 • 74 citations

Sodium valproate enhancement of gamma-aminobutyric acid (GABA) inhibition: electrophysiological evidence for anticonvulsant activity.

1981 • 71 citations

Behavioural and electrographic effects of L-5-hydroxytryptophan and D,L-parachlorophenyl-alanine on epileptic senegalese baboon (Papio papio)

1972 • 71 citations

Concentration of Metabolites of Valproic Acid in Plasma of Epileptic Patients

1981 • 70 citations

EEG and behavioral comparison of the effects of gamma-hydroxybutyrate, gamma-butyro-lactone and short chain fatty acids in the rat

1967 • 69 citations

CYCLIC NUCLEOTIDES IN MURINE BRAIN: THE TEMPORAL RELATIONSHIP OF CHANGES INDUCED IN ADENOSINE 3′,5′‐MONOPHOSPHATE AND GUANOSINE 3′,5′‐MONOPHOSPHATE FOLLOWING MAXIMAL ELECTROSHOCK OR DECAPITATION

1976 • 69 citations

Metabolism of branched medium chain length fatty acid. II—β-oxidation of sodium dipropylacetate in rats

1976 • 66 citations

EFFECT OF TREATMENT WITH SODIUM VALPROATE AND DIAZEPAM ON PLASMA CORTICOTROPIN IN NELSON'S SYNDROME

1981 • 66 citations

Effect of acute and chronic anticonvulsant administration on endogenous γ-hydroxybutyrate in rat brain

1980 • 66 citations

Valproic Acid

1979 • 66 citations

Valproic Acid: Reversibly Acting Drug?

1976 • 65 citations

The effects of sodium valproate on γ-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice

1982 • 64 citations

BIOCHEMICAL EFFECTS IN MAN and RAT OF THREE DRUGS WHICH CAN INCREASE BRAIN GABA CONTENT

1978 • 64 citations

Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.

1980 • 63 citations

A Primate Model for Testing Anticonvulsant Drugs

1975 • 63 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 63 citations

Antiepileptic Therapy

1980 • 63 citations

Differential effects of n‐dipropylacetate and amino‐oxyacetic acid on Gm‐aminobutyric acid levels in discrete areas of rat brain¹

1979 • 61 citations

Comparison of Sodium Valproate and Phenytoin as Single Drug Treatment in Epilepsy

1981 • 61 citations

Aminooxyacetic acid induced changes in γ-aminobutyrate metabolism at the subcellular level

1978 • 61 citations

Cyclic Nucleotides in Epileptic Brain: Effects of Pentylenetetrazol on Regional Cyclic AMP and Cyclic GMP Levels In Vivo

1977 • 61 citations

Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides

1979 • 61 citations

Determination of lower fatty acids, particularly the anti-epileptic dipropyl-acetic acid, in biological materials by means of micro diffusion and gas chromatography

1973 • 61 citations

Rectal administration of sodium valproate in status epilepticus

1978 • 59 citations

Clinical Pharmacological Aspects of Valproate Sodium

1977 • 59 citations

Sodium valproate

1980 • 59 citations

Transient abolition of generalized photosensitive epileptic discharge in humans by apomorphine, a dopamine‐receptor agonist

1980 • 58 citations

Absorption and Distribution of Antiepileptic Drugs

1975 • 57 citations

An analysis of the kinetics of the inhibition of rabbit brain γ-aminobutyrate aminotransferase by sodium n-dipropylacetate and some other simple carboxylic acids

1975 • 57 citations

Noradrenergic influences on sound-induced seizures.

1980 • 56 citations

Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor.

1979 • 56 citations

Sodium di-n-propylacetate (valproate) potentiates responses to GABA and muscimol on single central neurones

1980 • 56 citations

Effect of Valproate Sodium on Generalized Penicillin Epilepsy in the Cat

1978 • 55 citations

Central neurotransmitter turnover

1982 • 55 citations

Sodium valproate in the treatment of intractable seizure disorders

1978 • 54 citations

Possible GABA-mediated control of dopamine-dependent behavioural effects from the nucleus accumbens of the rat

1976 • 53 citations

Pharmacokinetics of sodium valproate in dog and mouse.

1978 • 53 citations

The mechanism of action of sodium valproate

1981 • 50 citations

Inhibition of the Glycine Cleavage System: Hyperglycinemia and Hyperglycinuria Caused by Valproic Acid

1980 • 50 citations

Effects of carbamazepine on valproic acid kinetics in normal subjects

1979 • 50 citations

Suppression of GABA-induced abstinence behaviour in naive rats by morphine and bicuculline

1977 • 50 citations

Inhibition by valproic acid of pyruvate uptake by brain mitochondria

1982 • 49 citations

Sodium valproate in the treatment of levodopa-induced dyskinesia.

1978 • 49 citations

Sodium Valproate in Schizophrenia: Some Biochemical Correlates

1980 • 49 citations

In vitro studies into the effect of inhibition of rat brain succinic semialdehyde dehydrogenase on GABA synthesis and degradation

1976 • 47 citations

EFFECTS OF CHRONIC TREATMENT WITH AMINO‐OXYACETIC ACID OR SODIUM n‐DIPROPYLACETATE ON BRAIN GABA LEVELS AND THE DEVELOPMENT AND REGRESSION OF COBALT EPILEPTIC FOCI IN RATS

1976 • 47 citations

Muscimol antagonizes the ergometrine-induced locomotor activity in nucleus accumbens: Evidence for a GABA-dopaminergic interaction

1977 • 47 citations

Effects of sodium dipropylacetate on .GAMMA.-aminobutyric acid and biogenic amines in rat brain.

1977 • 46 citations

Sodium valproate enhances responses to GABA receptor activation only at high concentrations

1982 • 44 citations

Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro

1973 • 44 citations

Identification of Metabolites of Valproic Acid in Serum of Humans, Dog, Rat, and Mouse

1978 • 44 citations

Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings

1981 • 44 citations

Anticonvulsant activity of metabolites of valproic acid.

1981 • 42 citations

Interactions of Di‐n‐Propylacetate, Gabaculine, and Aminooxyacetic Acid: Anticonvulsant Activity and the γ‐Aminobutyrate System

1981 • 42 citations

Studies on γ‐Aminobutyric Acid Transport in Cobalt Experimental Epilepsy in the Rat

1981 • 41 citations

Protein Binding of Valproic Acid in the Presence of Elevated Free Fatty Acids in Patient and Normal Human Serum

1981 • 41 citations

Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.

1982 • 41 citations

Effect of valproic acid on serotonin metabolism

1979 • 40 citations

Valproate Sodium in Huntington Chorea

1977 • 39 citations

Sodium Valproate and Clonazepam in the Treatment of Intractable Epilepsy

1977 • 39 citations

Central actions of valproate sodium

1979 • 39 citations

Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds

1978 • 39 citations

Therapeutic Monitoring of Valproic Acid

1980 • 38 citations

Treatment of Parkinson's Disease with Sodium Valproate: Clinical, Pharmacological, and Biochemical Observations

1979 • 38 citations

Sodium valproate exerts anti-conflict activity in rats without any concomitant rise in forebrain GABA level

1981 • 37 citations

Bioavailability of Valproic Acid Under Fasting/ Nonfasting Regimens

1980 • 37 citations

Reduction of the level of the glycine cleavage system in the rat liver resulting from administration of dipropylacetic acid: An experimental approach to hyperglycinemia

1979 • 37 citations

Mechanism of action of valproate

1980 • 37 citations

Central actions of valproic acid in man and in experimental models of epilepsy

1981 • 36 citations

Local cerebral circulation and metabolism in bicuculline-induced status epilepticus: relevance for development of cell damage.

1983 • 36 citations

Photically induced epilepsy in Papio papio as a model for drug studies.

1975 • 36 citations

Meal‐Dependent Absorption of Enteric‐Coated Sodium Valproate

1980 • 35 citations

Advances in Epileptology. XII Epilepsy International Symposium

1982 • 35 citations

Effects of anticonvulsants on the in vivo and in vitro release of gaba

1981 • 34 citations

Metabolism of Valproate Sodium in Rabbit, Rat, Dog, and Man

1977 • 34 citations

Effect of 2-methyl 2-ethyl caproic acid and 2-2-dimethyl valeric acid on audiogenic seizures and brain gamma aminobutyric acid

1974 • 34 citations

γ-Acid Metabolism in Subcellular Particles of Mouse Brain and Its Relationship to Convulsions

1977 • 34 citations

Identification of urinary metabolites of sodium dipropylacetate in man; potential sources of interference in organic acid screening procedures

1977 • 33 citations

Sodium valproate: Serial monitoring of EEG and serum levels

1979 • 33 citations

Efficacy Testing of Valproic Acid Compared to Ethosuximide in Monkey Model: II. Seizure, EEG, and Diurnal Variations

1977 • 33 citations

METABOLITE LEVELS IN BRAIN FOLLOWING EXPERIMENTAL SEIZURES: THE EFFECTS OF ISONIAZID AND SODIUM VALPROATE IN CEREBELLAR AND CEREBRAL CORTICAL LAYERS

1979 • 33 citations

Efficacies of agents related to GABA, dopamine, and acetylcholine in the treatment of tardive dyskinesia [proceedings].

1978 • 32 citations

Regional distribution in brain and effect of cerebral mitochondrial respiration of the anticonvulsive drug n-diproylacetate

1975 • 32 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 31 citations

Do anticonvulsant drugs exert protective effect against hypoxia?

1975 • 30 citations

Sodium Valproate and Tardive Dyskinesia

1978 • 29 citations

The presynaptic effects of valproic acid in the isolated frog spinal cord

1981 • 28 citations

[Dipropylacetamide in the treatment of manic-depressive psychosis].

1975 • 28 citations

Amino Acid Precursors: Their Transport into Brain and Initial Metabolism

1978 • 28 citations

Di-n-propylacetic acid--profile of anticonvulsant activity in mice.

1976 • 28 citations

Effect of sodium valporate on hypothalamic neurons in vivo and in vitro

1981 • 28 citations

FUNCTIONAL CHANGES IN CEREBRAL 5‐HYDROXYTRYPTAMINE METABOLISM IN THE MOUSE INDUCED BY ANTICONVULSANT DRUGS

1978 • 28 citations

Metabolism of sodium dipropylacetate in human

1978 • 27 citations

Hemiballismus treated with sodium valproate.

1981 • 27 citations

Saturable binding of [³H]phenytoin to rat brain membrane fraction

1981 • 25 citations

Action de l'Acide Dipropylacétique Chez le Papio papio Photosensible

1971 • 24 citations

Valproic acid in Sydenham's chorea.

1981 • 24 citations

[Action of dipropylacetic acid upon photosensitive Papio papio].

1971 • 24 citations

γ-Aminobutyric acid in subcellular fractions of mouse brain and its relation to convulsions

1979 • 23 citations

Studies on distribution and metabolism of valproate in rat brain, liver, and kidney

1980 • 23 citations

Effects of GAD and GABA-T inhibitors on GABA metabolism in vivo

1980 • 23 citations

Dipropylacetate and aminoaciduria

1980 • 23 citations

Studies on a New Anticonvulsant Drug, Sodium Dipropylacetate. Assay for Metabolites and Metabolic Pathway

1972 • 22 citations

Di-n-propylacetate-induced abstinence behaviour as a possible correlate of increased GABA-ergic activity in the rat

1980 • 22 citations

[Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome].

1978 • 22 citations

Pharmacokinetics and therapeutics in epilepsy

1979 • 22 citations

Antiepileptic Drugs, 2nd Edn

1983 • 22 citations

Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain

1982 • 22 citations

Binding of (3H)-5,5 diphenylhydantoin to rat brain membranes

1981 • 21 citations

AMINO ACIDS IN ‘LIGHT’ AND ‘HEAVY’ SYNAPTOSOME FRACTIONS FROM RAT OLFACTORY LOBES AND THEIR RELEASE BY ELECTRICAL STIMULATION

1976 • 21 citations

Effect of valproic acid on anxiety-related behaviors in the rat

1980 • 21 citations

The Turnover of Transmitter Amino Acids, with Special Reference to GABA

1981 • 21 citations

Prevention of kainic acid-induced seizure-like activity by antiepileptic drugs.

1980 • 21 citations

Dopamine Agonists in Reflex Epilepsy

1981 • 21 citations

Dipropylacetic Acid (Depakine®) in Experimental Epilepsy in the Alert Cat

1975 • 20 citations

Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action

1980 • 20 citations

Sodium di-n-propylacetate (valproate) action on single neurons in rat cerebral cortex and hippocampus

1979 • 20 citations

Anticonvulsant action of clobazam and desmethylclobazam in reflex epilepsy in rodents and baboons

1982 • 18 citations

The effects of phenytoin, 5-(para-hydroxyphenyl)-5-phynylhydantoin and valproic acid on humoral immunity in mice

1980 • 18 citations

Time course of the increase in GABA level in different mice brain regions following N-dipropylacetate treatment.

1978 • 18 citations

Effect of Anticonvulsants on Spiking Activity Induced by Cortical Freezing in Cats

1979 • 18 citations

Effect of sodium valproate on motor function regulated by the activation of GABA receptors

1981 • 18 citations

Evaluation of a synaptosomal model for monitoring in vivo changes in the gaba and glutamate content of nerve endings

1981 • 17 citations

Phenobarbitone binding sites in rat brain synaptosomal membranes

1981 • 17 citations

Increased Dipropylacetic Acid Bioavailability from Dipropylacetamide by Food

1982 • 17 citations

Drugs affecting GABA.

1980 • 17 citations

Suppression of retinal spike discharge by dipropylacetate (depakene): A possible involvement of GABA

1979 • 17 citations

Valproic acid serum levels and protection against kindled amygdaloid scizures in the rat

1981 • 17 citations

On a possible role of GABA in mania. Therapeutic efficacy of sodium valproate.

1981 • 17 citations

Solubilization of the Picrotoxinin Binding Receptor from Mammalian Brain

1981 • 16 citations

The Use of Sodium Valproate in a Case of Status Epilepticus

1976 • 16 citations

The effects of the anticonvulsant valproic acid on cerebral indole amine metabolism

1979 • 16 citations

The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat

1982 • 14 citations

An examination of the ‘wet dog’ shake behaviour in rats produced by acute administration of sodium n-dipropylacetate

1981 • 13 citations

[Studies on the urinary excretion of metabolites of valproic acid (dipropylacetic acid) in rats and humans (author's transl)].

1977 • 13 citations

Turnover Numbers of ?-Aminobutyrate Aminotransferase in Some Regions of Rat Brain

1980 • 12 citations

Oxidative Metabolism of 4‐Aminobutyrate by Rat Brain Mitochondria: Inhibition by Branched‐chain Fatty Acid

1980 • 12 citations

Etude des relations entre la structure cristalline et l'activite biologique de molecules des series di- et trialcoyl acetiques

1974 • 11 citations

Inhibition of high affinity uptake of GABA by branched fatty acids

1976 • 11 citations

Linear Relationship between Plasma Concentration and Dosage of Sodium Valproate

1979 • 10 citations

Valproic acid therapy in childhood epilepsy

1980 • 10 citations

Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment

1982 • 9 citations

Effects of branched-chain fatty acids on GABA-degradation and behavior: Further evidence for a role of GABA in quasi-morphine abstinence behavior

1980 • 9 citations

The effect of l-tryptophan on motor activity and its prevention by an extracerebral decarboxylase inhibitor and by 5-HT receptor blockers

1980 • 9 citations

Falsely Positive Wassermann and Kahn Reactions in Infective Hepatitis

1946 • 8 citations

Clinical Efficacy of Valproic Acid in Relation to Plasma Levels

1978 • 8 citations

The antiepileptic properties of N-dipropylacetamide (depamide): a clinical trial.

1980 • 7 citations

Variations de la teneur en GABA de certaines zones du cerveau de la souris sous l'effet de l'acide propyl-2-pentène-2 oïque.

1978 • 6 citations

The electrophysiological effects of ionophore X-537A on cardiac Purkinje fibres

1976 • 6 citations

Sodium valproate (Epilim) in epilepsy: a trial.

1978 • 6 citations

Electrophysiological and behavioural correlations during the manipulations of GABA functions in the Substantia Nigra by n-dipropylacetate and Picrotoxin

1979 • 6 citations

Effets du n-dipropylacétate de sodium sur le taux de GABA de certaines zones du cerveau de la souris

1976 • 5 citations

Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Involvement of amygdaloid and thalamic structures

1981 • 5 citations

The interaction of chlordiazepoxide and sodium valproate in the nucleus accumbens of the rat

1981 • 5 citations

GABA autoreceptors: structure-activity relationships for agonists.

1981 • 4 citations

Role of the GABA-ergic component in the development of the tranquilizing effect in cats

1981 • 3 citations

EPILEPSIE EXPERIMENTALE A L'GUABAINE CHEZ LA SOURIS. MODE D'ACTION DE L'ACIDE VALPROIQUE

1978 • 2 citations

Hospital Career Structure

1968 • 2 citations

Tranquilizing effect of n-dipropyl acetate and other GABA-ergic drugs in a conflict situation

1980 • 2 citations

New evidence of a GABA-ergic component in the mechanism of action of benzodiazepine tranquilizers

1981 • 1 citations

The Value of Meteorological Instruments in the Selection of Health Resorts

1892 • 1 citations