Stress, depression and the mesolimbic dopamine system

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

1987 • 1,858 citations

Food reward: Brain substrates of wanting and liking

1996 • 1,831 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Mesocorticolimbic dopaminergic network: functional and regulatory roles

1991 • 1,104 citations

Stressful life events, genetic liability, and onset of an episode of major depression in women

1995 • 1,057 citations

Responses of monkey dopamine neurons during learning of behavioral reactions

1992 • 986 citations

Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression

1981 • 838 citations

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

1987 • 682 citations

Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain

1981 • 659 citations

The role of dopamine in drug abuse viewed from the perspective of its role in motivation

1995 • 632 citations

An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress

1991 • 514 citations

Animal model of depression: Pharmacological sensitivity of a hedonic deficit

1982 • 452 citations

Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya

1993 • 398 citations

Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra

1985 • 355 citations

Animal models as simulations of depression

1991 • 328 citations

Changes in brain dopamine and acetylcholine release during and following stress are independent of the pituitary-adrenocortical axis

1991 • 323 citations

Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress

1990 • 308 citations

Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study

1993 • 262 citations

Repeated stressful experiences differently affect limbic dopamine release during and following stress

1992 • 251 citations

Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats

1992 • 249 citations

Effects of cocaine and footshock stress on extracellular dopamine levels in the ventral striatum

1991 • 238 citations

Animal models and human depressive disorders

1981 • 221 citations

Acute stress induces time-dependent responses in dopamine mesolimbic system

1991 • 213 citations

Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment

1980 • 208 citations

Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine

1994 • 201 citations

Multiple neurochemical and behavioral consequences of stressors: Implications for depression

1990 • 200 citations

Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion

1995 • 198 citations

Chronic treatment with antidepressants prevents the inhibitory effect of small doses of apomorphine on dopamine synthesis and motor activity

1979 • 193 citations

Coping and the Stress-Induced Potentiation of Stimulant Stereotypy in the Rat

1983 • 181 citations

The dopamine synapse and the notion of ‘pleasure centers’ in the brain

1980 • 173 citations

Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats

1986 • 169 citations

Region-specific reductions of intracranial self-stimulation after uncontrollable stress: Possible effects on reward processes

1983 • 167 citations

Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with on-line brain dialysis

1988 • 166 citations

Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system

1989 • 166 citations

Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex

1993 • 164 citations

Stressor-induced anhedonia in the mesocorticolimbic system

1991 • 139 citations

Electrical stimulation of reward sites in the ventral tegmental area increases dopamine transmission in the nucleus accumbens of the rat

1993 • 130 citations

Cold restraint alters dopamine metabolism in frontal cortex, nucleus accumbens and neostriatum

1983 • 125 citations

Opposite responses of mesolimbic dopamine system to controllable and uncontrollable aversive experiences

1994 • 124 citations

Chronic restraint stress elicits a positive antidepressant response on the forced swim test

1982 • 122 citations

Chronic stress depresses exploratory activity and behavioral performance in the forced swimming test without altering ACTH response to a novel acute stressor

1987 • 115 citations

Enhancement of amphetamine-induced locomotor activity and dopamine release in nucleus accumbens following excitotoxic lesions of the hippocampus

1993 • 113 citations

The opioid/nonopioid nature of stress-induced analgesia and learned helplessness.

1983 • 110 citations

A microdialysis study of ventral striatal dopamine during sexual behavior in female Syrian hamsters

1993 • 106 citations

Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens

1992 • 104 citations

Effects of immobilization stress on dopamine and its metabolites in different brain areas of the mouse: role of genotype and stress duration

1988 • 99 citations

Repeated stressful experiences differently affect the time-dependent responses of the mesolimbic dopamine system to the stressor

1993 • 94 citations

Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat

1996 • 91 citations

Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants

1990 • 91 citations

Tail-pinch stress increases extracellular DOPAC levels (as measured by in vivo voltammetry) in the rat nucleus accumbens but not frontal cortex: antagonism by diazepam and zolpidem

1987 • 87 citations

Changes in mesolimbic dopamine may explain stress-induced anhedonia

1991 • 79 citations

Voltammetric and microdialysis monitoring of brain monoamine neurotransmitter release during sociosexual interactions

1995 • 78 citations

Depletion of mesolimbic dopamine during behavioral despair: Partial reversal by chronic imipramine

1993 • 78 citations

Shuttle-box deficits induced by chronic variable stress: Reversal by imipramine administration

1991 • 73 citations

Changes in dopamine autoreceptor sensitivity in an animal model of depression

1988 • 73 citations

The effects of antidepressants and electroconvulsive shocks on the functioning of the mesolimbic dopaminergic system: A behavioral study

1987 • 72 citations

Different effects of repeated stressful experiences on mesocortical and mesolimbic dopamine metabolism

1996 • 71 citations

Strain-specific alterations in consumption of a palatable diet following repeated stressor exposure

1992 • 70 citations

Chronic stress induces strain-dependent sensitization to the behavioral effects of amphetamine in the mouse

1992 • 67 citations

Behavioral and biochemical changes monitored in two inbred strains of mice during exploration of an unfamiliar environment

1990 • 64 citations

Effects of defeat experiences on dopamine metabolism in different brain areas of the mouse

1990 • 62 citations

The role ofN-methyl-d-aspartate receptors in the regulation of physiologically released dopamine

1995 • 61 citations

Effect of different restraint schedules on the immobility in the forced swim test: Modulation by an opiate mechanism

1991 • 56 citations

Genotype-dependent effects of chronic stress on apomorphine-induced alterations of striatal and mesolimbic dopamine metabolism

1991 • 55 citations

Repeated treatment with imipramine or amitriptyline increases the locomotor response of rats to (+)-amphetamine given into the nucleus accumbens

1985 • 54 citations

Role of genotype in the adaptation of the brain dopamine system to stress

1990 • 52 citations

Activation, Coping, and Psychosomatics

1978 • 47 citations

A genetic analysis of stereotypy in the mouse: Dopaminergic plasticity following chronic stress

1985 • 45 citations

Enhanced functional responsiveness of the dopaminergic system—the mechanism of anti-immobility effects of antidepressants in the behavioural despair test in the rat

1988 • 44 citations

Neurobiological basis of stereotypies

1993 • 43 citations

Blockade of behavioral sensitization to methamphetamine by lesion of hippocampo-accumbal pathway

1991 • 40 citations

Effects of chronic variable stress and antidepressant drugs on behavioral inactivity during an uncontrollable stress: Interaction between both treatments

1992 • 39 citations

Tail pinch induced stress-arousal facilitates brain stimulation reward

1979 • 38 citations

Situation specific effects of stressor controllability on plasma corticosterone changes in mice

1990 • 35 citations

A comparison of the behavioral effects of minaprine, amphetamine and stress

1995 • 33 citations

Pharmacological, Biochemical, and Behavioral Analyses of Depression: Animal Models

1989 • 31 citations

Chronic stress reduces fighting behavior of rats: The effect of antidepressants

1991 • 21 citations

Nonhuman behavioral models in the genetics of disturbed behavior

1992 • 20 citations

Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test

1994 • 10 citations