The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

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2004 • 11,755 citations

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

2004 • 11,620 citations

Cancer-related inflammation

2008 • 10,288 citations

affy—analysis of Affymetrix GeneChip data at the probe level

2004 • 4,862 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Cytokines in the pathogenesis of rheumatoid arthritis

2007 • 2,377 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

2003 • 1,990 citations

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

2007 • 1,828 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Tumour necrosis factor and cancer

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TH-17 cells in the circle of immunity and autoimmunity

2007 • 1,520 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

Cytokines in cancer pathogenesis and cancer therapy

2004 • 1,465 citations

Induction and effector functions of TH17 cells

2008 • 1,197 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

The role of IL-6 and STAT3 in inflammation and cancer

2005 • 923 citations

Interleukin-17 family and IL-17 receptors

2003 • 905 citations

Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways

1999 • 881 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

TNF-α in promotion and progression of cancer

2006 • 814 citations

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

2008 • 808 citations

Interleukin-17 promotes angiogenesis and tumor growth

2002 • 795 citations

“Re-educating” tumor-associated macrophages by targeting NF-κB

2008 • 752 citations

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

2007 • 562 citations

Development of a syngeneic mouse model for events related to ovarian cancer

2000 • 555 citations

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

1999 • 532 citations

Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

2007 • 509 citations

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

2007 • 508 citations

Tumor-induced immune dysfunction: the macrophage connection

1998 • 433 citations

Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment

2007 • 410 citations

Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype

2006 • 393 citations

Anti-Cytokine Therapy for Rheumatoid Arthritis

2000 • 381 citations

The Inflammatory Cytokine Tumor Necrosis Factor-α Generates an Autocrine Tumor-Promoting Network in Epithelial Ovarian Cancer Cells

2007 • 366 citations

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics

2008 • 356 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids

2003 • 326 citations

Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils

2005 • 318 citations

IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GROα Chemokine from Mesothelial Cells

2000 • 304 citations

TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis

2006 • 295 citations

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

2005 • 274 citations

Generation and regulation of human CD4 ⁺ IL-17-producing T cells in ovarian cancer

2008 • 268 citations

Anti–Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

2008 • 245 citations

Tumor Necrosis Factor α As a New Target for Renal Cell Carcinoma: Two Sequential Phase II Trials of Infliximab at Standard and High Dose

2007 • 238 citations

Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development

2003 • 206 citations

TNF-α is critical for antitumor but not antiviral T cell immunity in mice

2007 • 206 citations

A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor α Inhibitor in Patients with Metastatic Breast Cancer

2004 • 193 citations

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

2008 • 186 citations

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer

2008 • 171 citations

An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.

2003 • 154 citations

Tumor Necrosis Factor-α Is a Potent Endogenous Mutagen that Promotes Cellular Transformation

2006 • 147 citations

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6

2007 • 124 citations

FDC-Specific Functions of p55TNFR and IKK2 in the Development of FDC Networks and of Antibody Responses

2006 • 120 citations

Colon Cancer Cell–Derived Tumor Necrosis Factor-α Mediates the Tumor Growth–Promoting Response in Macrophages by Up-regulating the Colony-Stimulating Factor-1 Pathway

2007 • 116 citations

Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells.

2002 • 116 citations

Low Levels of Tumor Necrosis Factor α Increase Tumor Growth by Inducing an Endothelial Phenotype of Monocytes Recruited to the Tumor Site

2008 • 114 citations

Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion

2007 • 106 citations

Ammonium Trichloro(dioxoethylene-o,o′)tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop

2004 • 94 citations

von Hippel-Lindau Protein-Mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed through Use of cDNA Arrays

2003 • 81 citations

Malignancy and biologic therapy in rheumatoid arthritis

2008 • 69 citations

Polymorphonuclear Neutrophils Improve Replication ofChlamydia pneumoniaeIn Vivo upon MyD88-Dependent Attraction

2005 • 66 citations

Tumor Necrosis Factor and Cancer

2007 • 45 citations

Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55

2004 • 40 citations

Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice

2008 • 14 citations