Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

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2000 • 27,569 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

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2004 • 4,599 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

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1998 • 2,698 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Promoting apoptosis as a strategy for cancer drug discovery

2005 • 1,102 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1993 • 1,049 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Herceptin acts as an anti-angiogenic cocktail

2002 • 608 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

The role of Bcl-2 family members in tumorigenesis

2003 • 536 citations

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

2002 • 393 citations

The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer

2004 • 260 citations

STI571 (Gleevec™) as a paradigm for cancer therapy

2002 • 244 citations

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

2006 • 172 citations

Receptor-mediated choreography of life and death.

2003 • 147 citations

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

2006 • 142 citations

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

2005 • 142 citations

Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis

2006 • 132 citations

Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors

2002 • 128 citations

Death receptors

2003 • 122 citations

Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

2003 • 121 citations

Neutralization of Smac/Diablo by Inhibitors of Apoptosis (IAPs)

2004 • 105 citations

Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic

2006 • 97 citations

Translating basic cancer research into new cancer therapeutics

2002 • 74 citations

Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma

2002 • 73 citations

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics

2004 • 43 citations

Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines

2006 • 35 citations

A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay

2003 • 33 citations

Targeting Macrophages with Microspheres Containing Cytokine-Neutralizing Antibodies Prevents Lethality in Gram-Negative Peritonitis

1999 • 24 citations