TNF-α in promotion and progression of cancer

Inflammation and cancer

2002 • 14,174 citations

Toll-like receptor signalling

2004 • 7,983 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 • 1,125 citations

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

2005 • 1,029 citations

Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial

2005 • 1,016 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

2004 • 813 citations

The significance of cancer cell expression of the chemokine receptor CXCR4

2004 • 740 citations

Journal of Clinical Oncology

1984 • 724 citations

Development of anti-TNF therapy for rheumatoid arthritis

2002 • 673 citations

Lymphoma in rheumatoid arthritis: The effect of methotrexate and anti–tumor necrosis factor therapy in 18,572 patients

2004 • 643 citations

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

2004 • 598 citations

Cellular and Molecular Biology

2014 • 562 citations

Tumor necrosis factor or tumor promoting factor?

2002 • 516 citations

Tumor Necrosis Factor

2004 • 491 citations

Tuberculosis infection in patients with rheumatoid arthritis and the effect of infliximab therapy

2004 • 437 citations

Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB

1998 • 435 citations

Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK

2005 • 415 citations

Serum levels of IL-6 and TNF-α correlate with clinicopathological features and patient survival in patients with prostate cancer

2004 • 391 citations

Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF- dependent up-regulation of matrix metalloproteases

2004 • 369 citations

Tumour necrosis factor α: a potential target for the therapy of solid tumours

2003 • 353 citations

Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids

2003 • 326 citations

Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils

2005 • 318 citations

Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice

2000 • 294 citations

NF-κB: tumor promoter or suppressor?

2004 • 251 citations

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β

2005 • 229 citations

Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development

2003 • 206 citations

Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

1997 • 205 citations

Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors.

2005 • 201 citations

Enhancement of experimental metastasis by tumor necrosis factor.

1993 • 198 citations

A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor α Inhibitor in Patients with Metastatic Breast Cancer

2004 • 193 citations

Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases

2004 • 189 citations

The clinical significance of tumor necrosis factor-α plasma level in patients having chronic lymphocytic leukemia

2002 • 180 citations

Tumor necrosis factor α is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system

1999 • 175 citations

Interleukin-6, tumour necrosis factor α and interleukin-1β in patients with renal cell carcinoma

2002 • 169 citations

Elevation of cytokine levels in cachectic patients with prostate carcinoma

2003 • 167 citations

Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway

2002 • 164 citations

Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation.

1993 • 161 citations

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

1990 • 154 citations

TNF and TNFR biology in health and disease.

2001 • 148 citations

The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells

2005 • 147 citations

Toll-like receptors, inflammation and cancer

2005 • 142 citations

Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR.

2003 • 133 citations

Expression and regulation of tumor necrosis factor α in normal and malignant ovarian epithelium

2006 • 127 citations

Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients.

2001 • 126 citations

Low‐dose thalidomide in combination with oral weekly cyclophosphamide and pulsed dexamethasone is a well tolerated and effective regimen in patients with relapsed and refractory multiple myeloma

2005 • 118 citations

Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells.

2002 • 116 citations

Both Lymphotoxin-α and TNF Are Crucial for Control ofToxoplasma gondiiin the Central Nervous System

2003 • 106 citations

Tumour necrosis factor-alpha, interleukin-6, and fasting serum insulin correlate with clinical outcome in metastatic breast cancer patients treated with chemotherapy

2004 • 101 citations

Donor-derived TNF-α regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation

2004 • 91 citations

TNF-α regulates epithelial expression of MMP-9 and integrin αvβ6 during tumour promotion. A role for TNF-α in keratinocyte migration?

2004 • 89 citations

Novel tumor necrosis factor‐knockout mice that lack Peyer's patches

2005 • 81 citations

von Hippel-Lindau Protein-Mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed through Use of cDNA Arrays

2003 • 81 citations

Cancer cachexia

2004 • 69 citations

Promotion of experimental liver metastasis by tumor necrosis factor

1995 • 62 citations

TNF-α induced DNA damage in primary murine hepatocytes

2003 • 61 citations

Tumor Necrosis Factor Sustains the Generalized Lymphoproliferative Disorder ( gld ) Phenotype

2000 • 59 citations

Cytokine Overexpression and Constitutive NFκB in Cancer

2004 • 58 citations

Remicade as TNF Suppressor in Patients with Myelodysplastic Syndromes

2004 • 56 citations

Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability

2002 • 52 citations

TNF-α targeted therapeutic approaches in patients with hematologic malignancies

2002 • 32 citations

Infliximab chimeric antitumor necrosis factor-α monoclonal antibody as potential treatment for myelodysplastic syndromes

2005 • 22 citations

Tumor Necrosis Factor-α Acts as a Complete Mitogen for Primary Rat Hepatocytes

2003 • 21 citations

The Current Status of Thalidomide in the Management of Multiple Myeloma

2005 • 14 citations