Autoinhibition of Bcr-Abl through Its SH3 Domain

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Hematologic and Cytogenetic Responses to Imatinib Mesylate in Chronic Myelogenous Leukemia

2002 • 2,056 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL

2003 • 624 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

2003 • 463 citations

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

1993 • 423 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

2002 • 262 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Autoinhibition of c-Abl

2002 • 244 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Structure of the Bcr-Abl oncoprotein oligomerization domain.

2002 • 137 citations

The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

2000 • 135 citations

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

2003 • 127 citations

The NH ₂ -Terminal Coiled-Coil Domain and Tyrosine 177 Play Important Roles in Induction of a Myeloproliferative Disease in Mice by Bcr-Abl

2001 • 126 citations

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia–like disease by bcr/abl

2002 • 121 citations

SH1 Domain Autophosphorylation of P210 BCR/ABL Is Required for Transformation but Not Growth Factor Independence

1993 • 116 citations

A Coiled-Coil Oligomerization Domain of Bcr Is Essential for the Transforming Function of Bcr-Abl Oncoproteins

1993 • 111 citations

The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase

2001 • 99 citations

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase

2001 • 90 citations

SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.

1993 • 77 citations

Amino Acid Substitutions within the Leucine Zipper Domain of the Murine Coronavirus Spike Protein Cause Defects in Oligomerization and the Ability To Induce Cell-to-Cell Fusion

1999 • 63 citations

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

2001 • 60 citations

Studying the pathogenesis of BCR–ABL+ leukemia in mice

2002 • 58 citations

Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

2001 • 53 citations

Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.

1995 • 52 citations

Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

1997 • 51 citations

Activation of c-Abl Kinase Activity and Transformation by a Chemical Inducer of Dimerization

2001 • 47 citations

Detection of c-abl Tyrosine Kinase Activity In Vitro Permits Direct Comparison of Normal and Altered abl Gene Products

1985 • 46 citations

Deletion of the ABL SH3 domain reactivates de‐oligomerized BCR‐ABL for growth factor independence

1996 • 21 citations