The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase

Oncogenes and signal transduction

1991 • 2,816 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Dominant negative MYC blocks transformation by ABL oncogenes

1992 • 410 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation

1998 • 397 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1996 • 259 citations

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1997 • 228 citations

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

1991 • 224 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

2000 • 135 citations

Signaling by ABL oncogenes through cyclin D1.

1995 • 78 citations

The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cells

1995 • 75 citations

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.

1995 • 67 citations

Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

1995 • 66 citations

PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl

1996 • 65 citations

Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. Detection of enzyme activity in detergent-solubilized cell extracts

1992 • 64 citations

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

1997 • 58 citations

v-Abl Activates c-myc Transcription through the E2F Site

1995 • 57 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 47 citations

Identification of a Novel Bone Marrow-Derived B-Cell Progenitor Population That Coexpresses B220 and Thy-1 and Is Highly Enriched for Abelson Leukemia Virus Targets

1996 • 47 citations

The SH2 domain of ABL is not required for factor-independent growth induced by BCR-ABL in a murine myeloid cell line.

1995 • 43 citations

The molecular pathogenesis of the philadelphia-positive leukemias: Implications for diagnosis and therapy

1993 • 23 citations

Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection

1998 • 9 citations