Activation of c-Abl Kinase Activity and Transformation by a Chemical Inducer of Dimerization

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

1993 • 423 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

1996 • 275 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Oligomeric Structure of the Human EphB2 Receptor SAM Domain

1999 • 233 citations

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRbeta oncoprotein

1997 • 220 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species

2000 • 158 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression

1998 • 124 citations

Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression

1998 • 96 citations

A general strategy for producing conditional alleles of Src-like tyrosine kinases.

1995 • 77 citations

Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.

1995 • 52 citations

Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants.

1993 • 51 citations

Retroviral Vectors for Production of Interleukin‐12 in the Bone Marrow to Induce a Graft‐Versus‐Leukemia Effecta

1996 • 43 citations

Cells Arrested in G1 by the v-Abl Tyrosine Kinase Do Not Express Cyclin A Despite the Hyperphosphorylation of RB

1996 • 42 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations

Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response.

1995 • 32 citations

Nuclear Localization of v-Abl Leads to Complex Formation with Cyclic AMP Response Element (CRE)-Binding Protein and Transactivation through CRE Motifs

1995 • 19 citations

A novel 53 kDa protein complexed with P210bcr-abl in human chronic myelogenous leukemia cells.

1988 • 10 citations

A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo.

1997 • 8 citations