IL-18: a key player in neuroinflammation and neurodegeneration?

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Interleukin-18 Regulates Both Th1 and Th2 Responses

2001 • 1,284 citations

Cytokines and acute neurodegeneration

2001 • 1,095 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Interleukin-18 Binding Protein

1999 • 759 citations

Interleukin-18

2003 • 581 citations

The Duality of the Inflammatory Response to Traumatic Brain Injury

2001 • 425 citations

Dual role of tumor necrosis factor alpha in brain injury

1999 • 411 citations

Closed head injury—an inflammatory disease?

2005 • 343 citations

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

2000 • 335 citations

Inflammation in central nervous system injury

2003 • 329 citations

A Role for IL-18 in Neutrophil Activation

2001 • 293 citations

Interleukin‐18 and Host Defense against Infection

2003 • 290 citations

Interleukin-18 Involvement in Hypoxic–Ischemic Brain Injury

2002 • 288 citations

Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

2001 • 286 citations

Role of glial cells in cerebral ischemia

2005 • 283 citations

Molecular Characterization of the Acute Inflammatory Response to Infections with Gram-Negative versus Gram-Positive Bacteria

2003 • 225 citations

Oxygen causes cell death in the developing brain

2004 • 215 citations

Caspase-1 Regulates the Inflammatory Process Leading to Autoimmune Demyelination

1999 • 198 citations

Delayed cytokine expression in rat brain following experimental contusion

1997 • 189 citations

Cultures of astrocytes and microglia express interleukin 18

1999 • 184 citations

Role of cytokines in preterm labour and brain injury

2005 • 181 citations

Elevated Intracranial IL-18 in Humans and Mice after Traumatic Brain Injury and Evidence of Neuroprotective Effects of IL-18—Binding Protein after Experimental Closed Head Injury

2002 • 176 citations

IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells

2000 • 173 citations

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

2003 • 166 citations

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

2003 • 164 citations

Murine Microglial Cells Produce and Respond to Interleukin‐18

1999 • 153 citations

Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.

1998 • 147 citations

Multiple sclerosis: Cytokine receptors on oligodendrocytes predict innate regulation

2003 • 141 citations

Cytokine and chemokine inter-regulation in the inflamed or injured CNS

2005 • 128 citations

Activation of Intrinsic and Extrinsic Proapoptotic Signaling Pathways in Interleukin-18-mediated Human Cardiac Endothelial Cell Death

2004 • 123 citations

Cloning and expression of interleukin‐18 binding protein

1999 • 122 citations

Neutralizing Antibodies to IFN-γ-Inducing Factor Prevent Experimental Autoimmune Encephalomyelitis

1998 • 117 citations

Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS

2005 • 105 citations

Caspase‐1–processed interleukins in hyperoxia‐induced cell death in the developing brain

2004 • 103 citations

Interleukin-18 Expression after Focal Ischemia of the Rat Brain: Association with the Late-Stage Inflammatory Response

2002 • 102 citations

Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS

2002 • 98 citations

Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo

2004 • 94 citations

Differential induction of interleukin-12, interleukin-18, and interleukin-1β converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat

1998 • 93 citations

Cloning of rat brain interleukin-18 cDNA

1998 • 92 citations

IL-18 in patients with multiple sclerosis

2001 • 91 citations

POSSIBLE CORRELATION BETWEEN HIGH LEVELS OF IL-18 IN THE CORD BLOOD OF PRE-TERM INFANTS AND NEONATAL DEVELOPMENT OF PERIVENTRICULAR LEUKOMALACIA AND CEREBRAL PALSY

2002 • 79 citations

Interleukin-18 in acute ischaemic stroke patients

2003 • 74 citations

The Role of Neuroinflammation in Traumatic Brain Injury

2004 • 74 citations

Interferon-γ–inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases

1999 • 73 citations

Regulation of IL-18 production by IFNγ and PGE2 in mouse microglial cells: involvement of NF-kB pathway in the regulatory processes

2001 • 70 citations

Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study

1999 • 67 citations

Inflammation in Stroke: The Good, the Bad, and the Unknown

2004 • 62 citations

Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment

2004 • 61 citations

Induction of the proinflammatory cytokine interleukin‐18 by axonal injury

2001 • 60 citations

Impaired Microglial Activation in the Brain of IL-18-Gene-Disrupted Mice after Neurovirulent Influenza A Virus Infection

2001 • 58 citations

Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis

2003 • 57 citations

Detection of the interleukin 18 family in rat brain by RT-PCR

2000 • 56 citations

Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices

2004 • 54 citations

Cytokine and Inducible Nitric Oxide Synthase mRNA Expression during Experimental Murine Cryptococcal Meningoencephalitis

2004 • 50 citations

White matter injury in the immature brain: role of interleukin-18

2004 • 49 citations

Interleukin‐18 induces expression and release of cytokines from murine glial cells: interactions with interleukin‐1β

2003 • 49 citations

No Role for Interleukin-18 in Acute Murine Stroke-Induced Brain Injury

2003 • 47 citations

Interleukin-18 is induced in acute inflammatory demyelinating polyneuropathy

2001 • 45 citations

Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury.

2004 • 41 citations

The Changing Face of Cytokines in the Brain: Perspectives From EAE

2005 • 38 citations

Identification of a truncated IL-18Rβ mRNA: a putative regulator of IL-18 expressed in rat brain

2003 • 36 citations

DIFFERENTIAL EFFECT OF CASPASE INHIBITION ON PROINFLAMMATORY CYTOKINE RELEASE IN SEPTIC PATIENTS

2000 • 32 citations

Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1–associated central nervous system disease

2004 • 22 citations

Immune and Inflammatory Responses in the Nervous System

2002 • 21 citations

Pro-Th1 Cytokines Promote Fas-Dependent Apoptosis of Immature Peripheral Basophils

2004 • 18 citations

Rat Interleukin-18 Binding Protein: Cloning, Expression, and Characterization

2002 • 15 citations

The Role of Interleukin-18 in Vesicular Stomatitis Virus Infection of the CNS

2001 • 13 citations

Neuronal expression of caspase-1 immunoreactivity in the rat central nervous system

2003 • 13 citations

The role of inflammation in neurologic disease

2000 • 11 citations

Inflammatory responses to traumatic brain injury: An overview for the new millenium

2002 • 7 citations