Neuronal expression of caspase-1 immunoreactivity in the rat central nervous system

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1964 • 5,110 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

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Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.

1978 • 656 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects.

1982 • 495 citations

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 • 450 citations

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

1988 • 414 citations

Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals

1963 • 383 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Anti-inflammatory actions of the neuroimmunomodulator α-MSH

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alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Non‐specific effects of methyl ketone peptide inhibitors of caspases

1999 • 298 citations

INTERLEUKIN-1F7B (IL-1H4/IL-1F7) IS PROCESSED BY CASPASE-1 AND MATURE IL-1F7B BINDS TO THE IL-18 RECEPTOR BUT DOES NOT INDUCE IFN-γ PRODUCTION

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Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein

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beta-Lipotropin: localization of cells and axons in rat brain by immunocytochemistry.

1977 • 236 citations

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1997 • 235 citations

The hypothalamic arcuate nucleus-median eminence complex: Immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons

1986 • 231 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

1986 • 221 citations

The hypothalamic arcuate nucleus-median eminence complex: Immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons

1986 • 210 citations

Suppression of food intake during infection: is interleukin-1 involved?

1985 • 199 citations

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1980 • 168 citations

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1984 • 166 citations

The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.

1995 • 158 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

A diffuse αMSH‐immunoreactive projection to the hippocampus and spinal cord from individual neurons in the lateral hypothalamic area and zona incerta

1984 • 137 citations

Immunohistochemical localization of interleukin-1β, interleukin-1 receptor antagonist and interleukin-1β converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid

1999 • 135 citations

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GABA and neuropeptides in the CNS

1985 • 133 citations

Hypothermic and antipyretic effects of centrally administered ACTH (1–24) and α-melanotropin

1981 • 130 citations

Immunoreactive β‐endorphin and acth in the same neurons of the hypothalamic arcuate nucleus in the rat

1979 • 128 citations

Immunocytochemical evidence that the same neurons in the human infundibular nucleus are stained with anti-endorphins and antisera of other related peptides

1978 • 115 citations

IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor.

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Antipyretic Role of Endogenous Melanocortins Mediated by Central Melanocortin Receptors during Endotoxin-Induced Fever

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Alpha-melanocyte-stimulating hormone exhibits target cell selectivity in its capacity to affect interleukin 1-inducible responses in vivo and in vitro.

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Cloning of rat brain interleukin-18 cDNA

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Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

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Interleukin-18 promotes sleep in rabbits and rats

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Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment.

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The Protective Effects of ??-Melanocyte Stimulating Hormone on Canine Brain Stem Ischemia

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IL-1β immunoreactive neurons in the human hypothalamus: reduced numbers in multiple sclerosis

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Effects of preoptic microinjections of α-MSH on fever and normal temperature control in rabbits

1987 • 51 citations

Localization of Interleukin-1βP Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels

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Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus

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Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice

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Neuropeptide regulation of interleukin-1 activities

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Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia

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Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS

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Endogenous α‐MSH modulates the Hypothalamic‐Pituitary‐Adrenal Response to the Cytokine Interleukin‐1β

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Neuropeptides in the median eminence☆

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Neurophysiology of fever.

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Inhibition of peripheral interleukin-10-induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone

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Cathepsin B immunoreactive neurons in rat brain. A combined light and electron microscopic study.

1989 • 15 citations

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