Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS

Antiviral Actions of Interferons

2001 • 2,683 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1998 • 1,118 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

Stat proteins and oncogenesis

2002 • 776 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

2003 • 763 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Gli and hedgehog in cancer: tumours, embryos and stem cells

2002 • 709 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Stat proteins and oncogenesis

2002 • 660 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

2001 • 576 citations

Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6

2002 • 575 citations

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation

2001 • 507 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.

1989 • 461 citations

Inflammation and Alzheimer's disease pathogenesis

1996 • 444 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.

1995 • 389 citations

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

1997 • 374 citations

Functional Roles of STAT Family Proteins: Lessons from Knockout Mice

1999 • 344 citations

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

2000 • 293 citations

Acquiring signalling specificity from the cytokine receptor gp130

2003 • 290 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Signaling pathways activated by interferons

1999 • 268 citations

Inflammation in traumatic brain injury: role of cytokines and chemokines.

1998 • 263 citations

Mutational switch of an IL-6 response to an interferon-γ-like response

2002 • 262 citations

Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.

1988 • 249 citations

Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.

1998 • 210 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 208 citations

Inflammatory Gene Expression in Cerebral Ischemia and Trauma

1997 • 207 citations

Transgenic Expression of IFN-α in the Central Nervous System of Mice Protects Against Lethal Neurotropic Viral Infection but Induces Inflammation and Neurodegeneration

1998 • 188 citations

Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

1996 • 184 citations

The role of IFN-γ in immune responses to viral infections of the central nervous system

2002 • 175 citations

Structural and functional neuropathology in transgenic mice with CNS expression of IFN-α1Published on the World Wide Web on 17 March 1999.1

1999 • 173 citations

Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)

2002 • 171 citations

Genetic models for CNS inflammation

2001 • 168 citations

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes

2002 • 155 citations

Ischemia‐induced neuronal expression of the microglia attracting chemokine secondary lymphoid‐tissue chemokine (SLC)

2001 • 136 citations

Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

1994 • 136 citations

STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities

1998 • 136 citations

Cytokines and STAT Signaling

1999 • 128 citations

Expression of Human Neurotropic Polyomavirus JCV Late Gene Product Agnoprotein in Human Medulloblastoma

2002 • 125 citations

Cytokines in the brain during viral infection: clues to HIV-associated dementia.

1997 • 122 citations

Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice.

1996 • 111 citations

STAT2 Acts as a Host Range Determinant for Species-Specific Paramyxovirus Interferon Antagonism and Simian Virus 5 Replication

2002 • 106 citations

IFN-γ Regulation of Class II Transactivator Promoter IV in Macrophages and Microglia: Involvement of the Suppressors of Cytokine Signaling-1 Protein

2001 • 104 citations

Cellular and humoral immune response in progressive multifocal leukoencephalopathy

2001 • 103 citations

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

1994 • 101 citations

Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis

2000 • 96 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1

1998 • 84 citations

Cellular Responses to Interferons and Other Cytokines: The JAK–STAT Paradigm

1998 • 81 citations

Transgenic Models to Study the Actions of Cytokines in the Central Nervous System

1998 • 80 citations

Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNS^a

1998 • 80 citations

Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis

2002 • 77 citations

Regional Hypomyelination and Dysplasia in Transgenic Mice with Astrocyte-Directed Expression of Interferon-γ

2000 • 77 citations

Cytokines and Chemokines as Mediators of Protection and Injury in the Central Nervous System Assessed in Transgenic Mice

2002 • 76 citations

Leukocyte Infiltration, But Not Neurodegeneration, in the CNS of Transgenic Mice with Astrocyte Production of the CXC Chemokine Ligand 10

2002 • 75 citations

Interferon‐α activates signal transducers and activators of transcription 5 and 6 in Daudi cells

1998 • 73 citations

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-α–stimulated STAT2-independent production of IFN-γ in the brain

2003 • 73 citations

Inducible production of interferon-γ in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway

2004 • 71 citations

Catalytically Active TYK2 Is Essential for Interferon-β-mediated Phosphorylation of STAT3 and Interferon-α Receptor-1 (IFNAR-1) but Not for Activation of Phosphoinositol 3-Kinase

1999 • 69 citations

AIDS‐Related Dementia and Calcium Homeostasis^a

1994 • 67 citations

Expression of ?suppressor of cytokine signalling? (SOCS) genes in the developing and adult mouse nervous system

2000 • 67 citations

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-α–stimulated STAT2-independent production of IFN-γ in the brain

2003 • 65 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 61 citations

Viral Inhibition of Interferon Signal Transduction

1999 • 59 citations

Cytokine signaling in the brain: Putting a SOCS in it?

2002 • 59 citations

STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-α in the central nervous system

2002 • 57 citations

Genes, Cells and Cytokines in Resistance against Development of Toxoplasmic Encephalitis

1999 • 30 citations

Mumps Virus Can Suppress the Effective Augmentation of HPC‐Induced Apoptosis by IFN‐γ through Disruption of IFN Signaling in U937 Cells

2000 • 19 citations

Cytokine-mediated inflammation and signaling in the intact central nervous system

2001 • 16 citations