TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

1999 • 705 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

The Cell Cycle

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

2001 • 436 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Chk2 activates E2F-1 in response to DNA damage

2003 • 377 citations

Emerging roles for E2F: Beyond the G1/S transition and DNA replication

2003 • 334 citations

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

2000 • 326 citations

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

2002 • 306 citations

RB and hbrm cooperate to repress the activation functions of E2F1

1997 • 293 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Differential regulation of E2F1 apoptotic target genes in response to DNA damage

2003 • 262 citations

BRG-1 is required for RB-mediated cell cycle arrest

2000 • 245 citations

Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function

1999 • 233 citations

Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

2003 • 227 citations

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

2001 • 217 citations

When the SWI/SNF complex remodels … the cell cycle

2001 • 196 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

1998 • 190 citations

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

2002 • 187 citations

Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals

1999 • 163 citations

Specificity in the activation and control of transcription factor E2F-dependent apoptosis

2003 • 151 citations

Apaf-1 Is a Mediator of E2F-1-induced Apoptosis

2002 • 138 citations

Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1

2003 • 135 citations

Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth

2002 • 130 citations

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

2002 • 128 citations

pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

2003 • 126 citations

Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication

2003 • 125 citations

A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1

2002 • 103 citations

A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.

1999 • 87 citations

Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.

2003 • 66 citations

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

2003 • 64 citations

Constitutive Protection of E2F Recognition Sequences in the Human Thymidine Kinase Promoter during Cell Cycle Progression

1997 • 56 citations

Identification of a protein-binding site in the promoter of the human thymidine kinase gene required for the G1-S-regulated transcription.

1992 • 43 citations