Specificity in the activation and control of transcription factor E2F-dependent apoptosis

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

2000 • 1,275 citations

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

2001 • 1,180 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

2001 • 931 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

The E2F1–3 transcription factors are essential for cellular proliferation

2001 • 595 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

2002 • 577 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

2001 • 436 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Opposing Effects of Ras on p53

2000 • 361 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1997 • 211 citations

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

2001 • 201 citations

Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

2002 • 196 citations

Phosphorylation of HDM2 by Akt

2002 • 193 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

1998 • 190 citations

E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability

2000 • 189 citations

Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

2000 • 173 citations

Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis

1994 • 160 citations

Direct repression of the Mcl-1 promoter by E2F1

2002 • 142 citations

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

2002 • 120 citations

Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor

2003 • 106 citations

Thymic lymphoma induction by the AKT8 murine retrovirus.

1988 • 100 citations

A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.

1999 • 87 citations

A Conserved Region of Unknown Function Participates in the Recognition of E2F Family Members by the Adenovirus E4 ORF 6/7 Protein

1996 • 16 citations