CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis*

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Chemokines

2000 • 3,773 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Human Chemokines: An Update

1997 • 2,235 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

1995 • 1,222 citations

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

1996 • 1,196 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3

1998 • 857 citations

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

1998 • 837 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

The codependence of angiogenesis and chronic inflammation

1997 • 695 citations

Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

1997 • 686 citations

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

1997 • 664 citations

Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).

1987 • 643 citations

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes.

1996 • 613 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity

2000 • 565 citations

Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells

1999 • 545 citations

Granulocyte Apoptosis and Its Role in the Resolution and Control of Lung Inflammation

1999 • 526 citations

Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD

2000 • 508 citations

Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats.

1983 • 487 citations

Chemokines: leucocyte recruitment and activation cytokines

1997 • 480 citations

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

1998 • 460 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

1999 • 420 citations

Signals and Receptors Involved in Recruitment of Inflammatory Cells

1995 • 420 citations

Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma

2000 • 419 citations

Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.

1997 • 415 citations

Chemokine Receptors in Human Endothelial Cells

1998 • 407 citations

The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor

1996 • 402 citations

Delayed Wound Healing in CXCR2 Knockout Mice

2000 • 401 citations

Interleukin-8. A corneal factor that induces neovascularization.

1992 • 385 citations

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

1997 • 380 citations

Cell cycle–dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity

2001 • 377 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.

1994 • 373 citations

Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer.

2000 • 361 citations

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis

1999 • 344 citations

P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis.

1996 • 329 citations

Angiogenesis inhibition: A review

1994 • 324 citations

Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors

1997 • 323 citations

Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth

1998 • 314 citations

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

1993 • 313 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

1990 • 302 citations

Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung

1998 • 291 citations

Induction of Apoptosis and Pulmonary Fibrosis in Mice in Response to Ligation of Fas Antigen

1997 • 289 citations

Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice.

1997 • 274 citations

CXC CHEMOKINE RECEPTOR EXPRESSION ON HUMAN ENDOTHELIAL CELLS

1999 • 271 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

1998 • 249 citations

Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor

2000 • 248 citations

Differential expression and responsiveness of chemokine receptors (CXCR1–3) by human microvascular endothelial cells and umbilical vein endothelial cells

2000 • 248 citations

Role of Interleukin-8 in Tumor Growth and Metastasis of Human Melanoma

1999 • 248 citations

Neutralization of the CXC Chemokine, Macrophage Inflammatory Protein-2, Attenuates Bleomycin-Induced Pulmonary Fibrosis

1999 • 243 citations

Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies.

1997 • 241 citations

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

1995 • 240 citations

Precapillary Systemic-pulmonary Anastomoses

1963 • 232 citations

IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis.

1999 • 232 citations

Cell cycle kinetics in the alveolar epithelium

1997 • 231 citations

Heterogeneous Proliferative Characteristics of Human Adult Lung Fibroblast Lines and Clonally Derived Fibroblasts from Control and Fibrotic Tissue

1988 • 228 citations

Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)

2001 • 219 citations

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

1994 • 219 citations

Basics of Cutaneous Wound Repair

1993 • 214 citations

IL-8 Is an Angiogenic Factor in Human Coronary Atherectomy Tissue

2000 • 214 citations

Pulmonary Fibrosis—A possible mechanism

1979 • 213 citations

Role of mesenchymal cell death in lung remodeling after injury.

1993 • 211 citations

Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression

1997 • 208 citations

Assays for angiogenesis: A review

1991 • 202 citations

Programmed Cell Death Contributes to Postnatal Lung Development

1998 • 195 citations

Angiotensin II induces apoptosis in human and rat alveolar epithelial cells

1999 • 193 citations

Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.

1994 • 190 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

HuMig: A New Human Member of the Chemokine Family of Cytokines

1993 • 188 citations

Interleukln-8 stimulates angiogenesis in rats

1993 • 182 citations

Neutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8

1992 • 180 citations

Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor

2001 • 171 citations

Point Mutation Causing Constitutive Signaling of CXCR2 Leads to Transforming Activity Similar to Kaposi’s Sarcoma Herpesvirus-G Protein-Coupled Receptor

1999 • 159 citations

Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint

2001 • 146 citations

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

1995 • 143 citations

Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue.

1998 • 141 citations

Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair.

1997 • 141 citations

Stimulation of neovascularization by human rheumatoid synovial tissue macrophages

1986 • 137 citations

Human Interferon-γ–inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma–associated Herpesvirus G Protein–coupled Receptor

1998 • 136 citations

IL-12 attenuates bleomycin-induced pulmonary fibrosis

2001 • 135 citations

Angiotensin II directly increases transforming growth factor β1 and osteopontin and indirectly affects collagen mRNA expression in the human heart

2000 • 134 citations

ENA-78 Is an Important Angiogenic Factor in Idiopathic Pulmonary Fibrosis

2001 • 132 citations

IL-8 specifically binds to endothelial but not to smooth muscle cells.

1995 • 129 citations

Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides

1999 • 128 citations

Angiotensin II and gene expression in the kidney

1998 • 128 citations

Apoptosis of lung epithelial cells in response to TNF‐α requires angiotensin II generation de novo

2000 • 127 citations

Angiogenesis in the Mouse Lung

2000 • 126 citations

Attenuation of Lung Inflammation and Fibrosis in Interferon- γ –Deficient Mice after Intratracheal Bleomycin

2001 • 124 citations

Endothelial-Monocyte Activating Polypeptide Ii, a Novel Antitumor Cytokine That Suppresses Primary and Metastatic Tumor Growth and Induces Apoptosis in Growing Endothelial Cells

1999 • 117 citations

Cultured Myofibroblasts Generate Angiotensin Peptidesde Novo

1997 • 115 citations

Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism

1998 • 114 citations

Bronchial vascular congestion and angiogenesis

1997 • 113 citations

Angiostatin: an endogenous inhibitor of angiogenesis and of tumor growth.

1997 • 111 citations

Monocrotaline-Induced Pulmonary Fibrosis in Rats: Amelioration by Captopril and Penicillamine

1985 • 110 citations

Mechanisms of Structural Remodeling in Chronic Pulmonary Hypertension

1999 • 109 citations

Angiogenesis as a Target for Tumor Treatment

1997 • 104 citations

Apoptosis: A Product of Programmed and Unprogrammed Cell Death

1993 • 104 citations

Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin

1994 • 103 citations

Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma

1997 • 101 citations

Chronic ethanol ingestion potentiates TNF-α-mediated oxidative stress and apoptosis in rat type II cells

2001 • 95 citations

Effect of Murine Gamma Interferon on the Cellular Responses to Bleomycin in Mice

1988 • 90 citations

Angiogenesis in bronchial circulatory system after unilateral pulmonary artery obstruction

1997 • 87 citations

Tumor angiogenesis - a new therapeutic target in gliomas

2009 • 87 citations

Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair.

1995 • 83 citations

A Collection of mRNA Species That Are Inducible in the RAW 264.7 Mouse Macrophage Cell Line by Gamma Interferon and Other Agents

1992 • 82 citations

Inhibition of Constitutive Signaling of Kaposi's Sarcoma–associated Herpesvirus G Protein–Coupled Receptor by Protein Kinases in Mammalian Cells in Culture

1998 • 80 citations

Regulation of apoptosis by vasoactive peptides

2001 • 72 citations

Interleukin‐8 and de novo mammalian angiogenesis

1996 • 71 citations

Characterization of cell populations isolated from aortas of rhesus monkeys with experimental atherosclerosis.

1980 • 70 citations

Angiogenic molecules and cancer metastasis.

1998 • 65 citations

The effect of Captopril on benign and malignant reactions in irradiated rat skin

1990 • 58 citations

Inhibition of wound healing in mice by local interferon alpha/beta injection.

1993 • 57 citations

The molecular and cellular biology of the chemokines

1998 • 51 citations

Interleukin-8 Receptors R1 and R2 Activate Mitogen-Activated Protein Kinases and Induce c-fos, Independent of Ras and Raf-1 in Chinese Hamster Ovary Cells

1998 • 50 citations

Responses of the lung to toxic injury.

1990 • 49 citations

Alveolar epithelial type II cell apoptosis in vivo during resolution of keratinocyte growth factor-induced hyperplasia in the rat

2000 • 48 citations

Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12

2001 • 47 citations

LIGATION OF THE PULMONARY ARTERY OF ONE LUNG WITH AND WITHOUT RESECTION OF THE PHRENIC NERVE

1924 • 46 citations

[14] In vitro and in vivo systems to assess role of CXC chemokines in regulation of angiogenesis

1997 • 43 citations

Angiogenesis Is Coming of Age

1998 • 42 citations

Clinical implications of tumor-associated neovascularization and current antiangiogenic strategies for the treatment of malignancies of pancreas

1996 • 39 citations

Segmental vascular resistance in postobstructive pulmonary vasculopathy

1990 • 37 citations

TNF-α increases ceramide without inducing apoptosis in alveolar type II epithelial cells

1999 • 36 citations

Pulmonary injury and repair. Organ culture studies of murine lung after oxygen.

1976 • 31 citations

Transcription factors modulating angiotensinogen gene expression in hepatocytes

1994 • 28 citations

New p53-based anti-cancer therapeutic strategies

1998 • 19 citations

Tumorangiogenesis: A Network of Cytokines

1997 • 16 citations

Angiogenesis inhibitors. A promising role in cancer therapy.

1998 • 11 citations

[Neovascularization of tumors. New therapeutic possibilities].

1999 • 4 citations