Basics of Cutaneous Wound Repair

Angiogenic Factors

1987 • 3,702 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

1990 • 2,262 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

Integrins.

1991 • 1,369 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

1984 • 1,136 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Cytokines in context.

1991 • 808 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

Transforming growth factor α

1988 • 707 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Fibronectin and Fibrin Provide a Provisional Matrix for Epidermal Cell Migration During Wound Reepithelialization

1982 • 695 citations

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages

1983 • 689 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE

1989 • 593 citations

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

1989 • 591 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Role of platelet‐derived growth factor in wound healing

1991 • 569 citations

Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions.

1978 • 567 citations

Induction of tenascin in healing wounds.

1988 • 563 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

1989 • 539 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

Distribution of Fibronectin During Wound Healing in Vivo

1981 • 474 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Sequential appearance of fibronectin and collagen in experimental granulation tissue.

1980 • 449 citations

Mast cell heparin stimulates migration of capillary endothelial cells in vitro.

1980 • 445 citations

Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines

1989 • 435 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

Chemotactic Response to Human C3a and C5a Anaphylatoxins

1978 • 393 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Changes in Keratinocyte Maturation During Wound Healing

1987 • 375 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

A PATTERN OF EPIDERMAL CELL MIGRATION DURING WOUND HEALING

1971 • 365 citations

Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction.

1990 • 363 citations

Peptide growth factors and inflammation, tissue repair, and cancer.

1986 • 360 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.

1991 • 355 citations

Fibroblast adhesion to fibrinogen and fibrin substrata: Requirement for cold-insoluble globulin (plasma fibronectin)

1980 • 355 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Cytokine Modulation of Keratinocyte Cytokines

1990 • 345 citations

EGF and TGF‐α in wound healing and repair

1991 • 340 citations

Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing.

1978 • 328 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

Fibronectin Matrix Deposition and Fibronectin Receptor Expression in Healing and Normal Skin

1990 • 314 citations

Cytoadhesins, Integrins, and Platelets

1988 • 306 citations

Association of factor XI and high molecular weight kininogen in human plasma.

1977 • 281 citations

Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation.

1985 • 278 citations

ANGIOGENESIS: INITIATION AND CONTROL*

1982 • 264 citations

In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface.

1984 • 261 citations

Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.

1987 • 255 citations

Activation of the classical pathway of complement by Hageman factor fragment.

1981 • 255 citations

Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo

1988 • 246 citations

Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

1988 • 244 citations

Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration.

1988 • 237 citations

Collagen Biosynthesis by Cells in a Tissue Equivalent Matrix In Vitro

1984 • 233 citations

Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing

1991 • 230 citations

Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices.

1989 • 224 citations

Chemotactic response of monocytes to thrombin.

1983 • 221 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines.

1989 • 205 citations

Human monocyte inflammatory mediator gene expression is selectively regulated by adherence substrates.

1989 • 192 citations

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

1987 • 181 citations

Chemotaxis of aortic endothelial cells in response to fibronectin.

1982 • 178 citations

The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 • 175 citations

Stimulation of Growth of Keratinocytes by Basic Fibroblast Growth Factor

1988 • 172 citations

Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes.

1988 • 168 citations

Stimulatory Effects of Transforming Growth Factor-beta and Epidermal Growth Factor on Epidermal Cell Outgrowth from Porcine Skin Explant Cultures

1988 • 165 citations

Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors.

1988 • 164 citations

Hemidesmosome and desmosome morphogenesis during epidermal wound healing

1973 • 161 citations

Spreading and Enhanced Motility of Human Keratinocytes on Fibronectin

1985 • 158 citations

The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases

1988 • 156 citations

Fibronectin is produced by blood vessels in response to injury.

1982 • 155 citations

Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120-kDa fibroblastic cell-binding fragment.

1988 • 153 citations

Basic Fibroblast Growth Factor Stimulation of Epidermal Wound Healing in Pigs

1990 • 145 citations

The sequence of events in the regression of corneal capillaries.

1978 • 141 citations

Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration.

1986 • 131 citations

Human monocyte adherence: a primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium.

1987 • 128 citations

Release of leukotrienes from guinea pig lung stimulated by C5ades Arg anaphylatoxin.

1982 • 124 citations

Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration.

1988 • 117 citations

Synergistic Effects of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor I/Somatomedin C (IGF-I) on Keratinocyte Proliferation May Be Mediated by IGF-I Transmodulation of the EGF Receptor

1991 • 117 citations

Hemidesmosomes and anchoring fibril collagen appear synchronously during development and wound healing

1988 • 116 citations

The activation of the alternative pathway C3 convertase by human plasma kallikrein.

1982 • 113 citations

Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism.

1989 • 112 citations

Interaction of antithrombin III with bovine aortic segments. Role of heparin in binding and enhanced anticoagulant activity.

1985 • 110 citations

Adult tissues contain chemo-attractants for vascular endothelial cells

1980 • 108 citations

Adult Human Keratinocytes Migrating over Nonviable Dermal Collagen Produce Collagenolytic Enzymes That Degrade Type I and Type IV Collagen

1986 • 103 citations

Aortic endothelial cell migration. I. Matrix requirements and composition.

1982 • 103 citations

Endothelial cell behavior after denudation injury is modulated by transforming growth factor-beta1 and fibronectin.

1989 • 101 citations

Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.

1990 • 98 citations

Collagen Telopeptides (Cross-Linking Sites) Play a Role in Collagen Gel Lattice Contraction

1991 • 97 citations

Transforming Growth Factor-β Stimulates the Expression of Fibronectin by Human Keratinocytes

1988 • 87 citations

Induction of Lysosomal Enzyme Secretion by Alveolar Macrophages in Response to the Purified Complement Fragments C5a and C5a des-arg

1979 • 87 citations

Neutrophil-Endothelial Cell Interactions: Mechanisms of Neutrophil Adherence to Vascular Endothelium.

1989 • 81 citations

Fibronectin receptors of human keratinocytes and their expression during cell culture.

1987 • 81 citations

Monocyte procollagenase and tissue inhibitor of metalloproteinases. Identification, characterization, and regulation of secretion.

1987 • 79 citations

Enhanced Synthesis of Collagenase by Human Keratinocytes Cultured on Type I or Type IV Collagen

1990 • 76 citations

Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture.

1989 • 60 citations

Human endothelial cell migration: stimulation by a released platelet factor.

1978 • 57 citations

Behavior of cells seeded in isolated fibronectin matrices.

1983 • 56 citations

Either exogenous or endogenous fibronectin can promote adherence of human endothelial cells

1986 • 52 citations

Regulation of proliferation of bovine aortic endothelial cells, smooth muscle cells, and adventitial fibroblasts in collagen lattices

1985 • 49 citations

Vitronectin: Effects on Keratinocyte Motility and Inhibition of Collagen-Induced Motility

1991 • 48 citations

Relationship of one form of human histamine-releasing factor to connective tissue activating peptide-III.

1990 • 47 citations

Neutrophil Emigration, Activation, and Tissue Damage

1988 • 29 citations

Angiogenesis

1988 • 25 citations

Factors That Affect Vessel Reactivity and Leukocyte Emigration

1988 • 10 citations

The Role of Cell-Cell Interaction in the Regulation of Endothelial Cell Growth

1988 • 6 citations