The molecular ZPA

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

Molecular Models for Vertebrate Limb Development

1997 • 592 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

The world according to bedgebog

1997 • 549 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Analysis of Hox gene expression in the chick limb bud

1996 • 480 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

1990 • 478 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb

1995 • 469 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Colinearity and functional hierarchy among genes of the homeotic complexes

1994 • 450 citations

Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod

1995 • 430 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 335 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

1995 • 318 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 314 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

1995 • 303 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Dorsal cell fate specified by chick Lmxl during vertebrate limb development

1995 • 287 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system

1994 • 272 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

Cell Death in Morphogenesis

1966 • 232 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

1997 • 196 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

BMP signaling during bone pattern determination in the developing limb

1996 • 180 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.

1967 • 172 citations

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

1998 • 169 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt)

1992 • 164 citations

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning

1995 • 160 citations

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

1990 • 151 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop

1997 • 131 citations

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.

1992 • 130 citations

Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb

1996 • 130 citations

Hox Codes and Positional Specification in Vertebrate Embryonic Axes

1992 • 126 citations

Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A

1995 • 117 citations

Multigenic Control of the Localization of the Zone of Polarizing Activity in Limb Morphogenesis in the Mouse

1997 • 115 citations

Positional signalling by Hensen’s node when grafted to the chick limb bud

1986 • 110 citations

Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation

1997 • 109 citations

The hedgehog gene family in Drosophila and vertebrate development

1994 • 109 citations

Phosphorylation of the fused protein kinase in response to signaling from hedgehog.

1996 • 105 citations

How to Make a Limb?

1994 • 105 citations

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation

1996 • 103 citations

Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud

1994 • 97 citations

Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity

1995 • 97 citations

Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.

1993 • 85 citations

Hedgehog and patched gene expression in adult ocular tissues

1997 • 73 citations

The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment.

1995 • 72 citations

Gene Expression in thelimblessMutant: Polarized Gene Expression in the Absence of Shh and an AER

1996 • 66 citations

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

1991 • 65 citations

Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb

1997 • 58 citations

Positional signal transmission in the developing chick limb

1981 • 55 citations

Posterior apical ectodermal ridge removal in the chick wing bud triggers a series of events resulting in defective anterior pattern formation

1987 • 53 citations

Functional Domains of Fused, a Serine-Threonine Kinase Required for Signaling in Drosophila

1996 • 52 citations

MRC-5 Cells Induce the AER prior to the Duplicated Pattern Formation in Chick Limb Bud

1995 • 40 citations

Hensen's node, but not other biological signallers, can induce supernumerary digits in the developing chick limb bud

1990 • 18 citations

The target tissue of limb-bud polarizing activity in the induction of supernumerary structures

1979 • 8 citations