Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

A series of normal stages in the development of the chick embryo

1992 • 1,860 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Wnt genes

1992 • 799 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Vertebrate Limb and Somite Morphogenesis

1979 • 613 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs

1994 • 330 citations

Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum

1991 • 325 citations

The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm

1993 • 292 citations

Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system

1994 • 272 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes

1993 • 198 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Ectodermal control of the dorsoventral axis in the leg bud of the chick embryo,

1974 • 159 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud

1994 • 97 citations

Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo

1992 • 91 citations

Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo.

1993 • 83 citations

Maintenance of ZPA signaling in cultured mouse limb bud cells

1993 • 41 citations

Normal development of the skeleton in chick limb buds devoid of dorsal ectoderm

1986 • 40 citations