Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

Genomic sequencing.

1984 • 8,343 citations

Ontogeny and Phylogeny

1977 • 3,887 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Vertebrate Limb and Somite Morphogenesis

1979 • 613 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

A Morphogenetic Approach to the Origin and Basic Organization of the Tetrapod Limb

1986 • 604 citations

Development and evolution

1982 • 601 citations

Murine Developmental Control Genes

1990 • 594 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

Mechanical aspects of mesenchymal morphogenesis

1983 • 501 citations

The Theory of Recapitulation: A Critical Re-statement of the Biogenetic Law.

1922 • 415 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

1993 • 352 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

Positional information revisited

1989 • 322 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

1992 • 307 citations

Ontogeny and phylogeny

1978 • 304 citations

HOX-4 genes and the morphogenesis of mammalian genitalia.

1991 • 292 citations

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

1992 • 289 citations

Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice

1989 • 262 citations

Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan

1988 • 245 citations

Spatially Regulated Expression of Homeotic Genes in Drosophila

1985 • 242 citations

Why we have (only) five fingers per hand: Hox genes and the evolution of paired limbs

1992 • 189 citations

A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions

1985 • 183 citations

Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads.

1989 • 176 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

Size dependence during the development of the amphibian foot. Colchicine-induced digital loss and reduction

1983 • 163 citations

Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene

1992 • 160 citations

The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

1991 • 135 citations

Developmental Patterning of the Vertebrate Limb

1991 • 131 citations

Ontogeny of the limb skeleton in Alligator mississippiensis: Developmental invariance and change in the evolution of archosaur limbs

1990 • 130 citations

Positional signalling by Hensen’s node when grafted to the chick limb bud

1986 • 110 citations

Homeobox genes and pattern formation in the vertebrate limb

1992 • 103 citations

Morphogenesis of the Vertebrate Limb

1975 • 99 citations

The development and homology of the chelonian carpus and tarsus

1985 • 95 citations

Complementary homeo protein gradients in developing limb buds.

1989 • 88 citations

Ectoderm as a determinant of early tissue pattern in the limb bud

1984 • 83 citations

The effect of neonatal treatment of male mice with antiandrogens and of females with androgens on the development of the os penis and os clitoridis.

1976 • 49 citations

Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms

1992 • 45 citations

Evolutionary Transformation of Limb Pattern: Heterochrony and Secondary Fusion

1991 • 42 citations

Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth.

1992 • 41 citations

The Interdigital Spaces of the Chick Leg Bud as a Model for Analysing Limb Morphogenesis and Cell Differentiation

1991 • 29 citations

The Implications of “The Bauplan” for Development and Evolution of the Tetrapod Limb

1991 • 24 citations

The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction

1992 • 22 citations

Limbs: a pattern emerges

1989 • 20 citations

Structural and Functional Aspects of Mammalian Hox Genes

1993 • 11 citations