Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The Genetics and Biology of Drosophila

1978 • 3,910 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

Pattern Regulation in Epimorphic Fields

1976 • 871 citations

G proteins

1992 • 871 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Developmental Compartmentalisation of the Wing Disk of Drosophila

1973 • 770 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Control of compartment development by the engrailed gene in Drosophila

1975 • 429 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila

1993 • 359 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-β family in Drosophila

1991 • 330 citations

Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs

1994 • 330 citations

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

1994 • 306 citations

Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory

1993 • 302 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions

1993 • 292 citations

Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless

1993 • 271 citations

Cell determination boundaries as organizing regions for secondary embryonic fields

1983 • 267 citations

A wingless -Dependent Polar Coordinate System in Drosophila Imaginal Discs

1993 • 266 citations

Allocation of the thoracic imaginal primordia in the Drosophila embryo

1993 • 248 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1994 • 212 citations

Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation

1988 • 211 citations

Altering the insertional specificity of a Drosophila transposable element.

1992 • 198 citations

Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.

1988 • 190 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary

1990 • 170 citations

Genetic investigation of cAMP-dependent protein kinase function in Drosophila development.

1993 • 155 citations

The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs

1990 • 144 citations

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

1992 • 133 citations

RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization.

1994 • 124 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Morphology and chaetotaxy of the legs of Drosophila melanogaster

1958 • 106 citations

The Drosophila melanogaster actin 5C gene uses two transcription initiation sites and three polyadenylation sites to express multiple mRNA species.

1986 • 97 citations

Pattern Formation in Imaginal Discs

2023 • 79 citations

patched Overexpression Causes Loss of wingless Expression in Drosophila Embryos

1994 • 32 citations

Unrestricted expression of the Drosophila gene patched allows a normal segment polarity

1991 • 30 citations

Deleted Work

1955 • 0 citations