The DNA (cytosine-5) methyltransferases

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

1991 • 1,482 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint

1986 • 1,172 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

The CpG dinucleotide and human genetic disease

1988 • 946 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

RESTRICTION AND MODIFICATION SYSTEMS

1991 • 702 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

A structural taxonomy of DNA-binding domains

1991 • 615 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

A Suggested nomenclature for bacterial host modification and restriction systems and their enzymes

1973 • 457 citations

Kinetic and catalytic mechanism of HhaI methyltransferase.

1987 • 416 citations

Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine

1993 • 357 citations

High frequency mutagenesis by a DNA methyltransferase

1992 • 259 citations

Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes

1989 • 254 citations

Isolation and identification by sequence homology of a putative cytosine methyltransferase fromArabidopsis thaliana

1993 • 253 citations

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1992 • 250 citations

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1991 • 246 citations

Organization of restriction-modification systems

1991 • 241 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

1990 • 227 citations

Cloning, characterization, and expression inEscherichia coliof the gene coding for the CpG DNA methylase fromSpiroplasma sp.strain MQ1(M Sssl)

1990 • 214 citations

Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases

1989 • 152 citations

A specific endonuclease from Haemophilus haemolyticus

1976 • 145 citations

Nudeotide sequence of the BsuRI restriction-modification system

1985 • 135 citations

Methylation of DNA in Prokaryotes

1993 • 123 citations

Sequential order of target-recognizing domains in multispecific DNA-methyltransferases.

1988 • 116 citations

The sequence specificity domain of cytosine-C5 methylases

1991 • 108 citations

Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for convalent catalysis

1987 • 108 citations

A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene

1990 • 108 citations

Nucleotide sequence and expression of the gene encoding theEcoRII modification enzyme

1987 • 106 citations

Construction and use of chimeric SPR/phi 3T DNA methyltransferases in the definition of sequence recognizing enzyme regions.

1987 • 96 citations

Cloning, sequencing, in vivo promoter mapping, and expression in Escherichia coli of the gene for the HhaI methyltransferase.

1987 • 90 citations

The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter.

1992 • 77 citations

The cysteine conserved among DNA cytosine methylasesis required for methyl transfer, but not for specific DNA binding

1993 • 76 citations

Organization of multispecific DNA methyltransferases encoded by temperate Bacillus subtilis phages.

1987 • 74 citations

Chimeric multispecific DNA methyltransferases with novel combinations of target recognition

1988 • 72 citations

DNA methyltransferase genes of Bacillus subtilis phages: comparison of their nucleotide sequences

1986 • 69 citations

Restriction and modification in Bacillus subtilis: nucleotide sequence, functional organization and product of the DNA methyltransferase gene of bacteriophage SPR

1984 • 67 citations

Structure of the Bacillus sphaericus R modification methylase gene

1983 • 65 citations

Substitutions of a cysteine conserved among DNA cytosine methylases result in a variety of phenotypes

1992 • 62 citations

Purification, crystallization, and preliminary x-ray diffraction analysis of an M.HhaI-AdoMet complex

1992 • 59 citations

Nuclotide sequence of theDdeI restriction-modification system and characterization of the methylase protein

1987 • 56 citations

The DNA binding affinity ofHhalmethylase is increased by a single amino acid substitution in the catalytic center

1993 • 55 citations

How M.Mspl and M.Hpall decide which base to methylate

1992 • 54 citations

Structure of the gene coding for the sequence-specific DNA-methyltransferase of theB. subtilisphage SPR

1984 • 53 citations

Agmenellum quadruplicatum M.AquI, a novel modification methylase

1990 • 51 citations

Cloning and complete nucleotide sequences of the type II restriction-modification genes of Salmonella infantis

1988 • 51 citations

Cloning, expression and characterization of the Sau3AI restriction and modification genes in Staphylococcus carnosus TM300

1990 • 49 citations

Cloning and characterization of the genes encoding theMspl restriction modification system

1989 • 49 citations

Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase

1992 • 48 citations

Identification of a highly conserved domain in the EcoRII methyltransferase which can be photolabeled with S-adenosyl-L-[methyl-3H]methionine. Evidence for UV-induced transmethylation of cysteine 186.

1991 • 47 citations

ScrFI restriction-modification system of Lactococcus lactis subsp. cremoris UC503: cloning and characterization of two ScrFI methylase genes

1993 • 46 citations

Characterization of the archaeal, plasmid-encoded type II restriction-modification system MthTI from Methanobacterium thermoformicicum THF: homology to the bacterial NgoPII system from Neisseria gonorrhoeae

1992 • 46 citations

Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C⁵methyltransferase ofE.coliK-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidine

1993 • 42 citations

Sequence analysis of theNgoPII methyltransferase gene fromNeisseria gonorrhoeaeP9: homologies with other enzymes recognizing the sequence 5′-GGCC-3′

1988 • 39 citations

Cloning and nucleotide sequence of the genes coding for theSau961 restriction and modification enzymes

1990 • 39 citations

Cloning and characterization of theHpallmethylase gene

1990 • 38 citations

Cloning and analysis of the HaeIII and HaeII methyltransferase genes

1988 • 38 citations

The amino acid sequence of the CCGG recognizing DNA methyltransferase M.BsuFI: implications for the analysis of sequence recognition by cytosine DNA methyltransferases.

1990 • 35 citations

Roles of Cys148 and Asp179 in catalysis by deoxycytidylate hydroxymethylase from bacteriophage T4 examined by site-directed mutagenesis

1992 • 33 citations

Cloning and characterization of two tandemly arranged DNA methyltransferase genes of Neisseria lactamica: An adenine-specific M.NlaIII and a cytosine-type methylase

1990 • 33 citations

The HgaI restriction-modification system contains two cytosine methylase genes responsible for modification of different DNA strands

1991 • 33 citations

Analysis of the nucleotide and derived amino acid sequences of the SsoII restriction endonuclease and methyltransferase

1993 • 31 citations

'Pseudo' domains in phage-encoded DNA methyltransferases

1991 • 31 citations

Cloning and sequencing the cytosine methyltransferase gene M.CviJI from Chlorella virus IL-3A

1990 • 29 citations

High plasticity of multispecific DNA methyltransferases in the region carrying DNA target recognizing enzyme modules.

1992 • 29 citations

Neucleotide sequence of thedcmlocus ofEsherichia coliK12

1989 • 28 citations

M · H2I, a multispecific 5C-DNA methyltransferase encoded by Bacillus amyloliquefaciens phage H2

1991 • 22 citations

Isolation and genetic structure of theAvallisoschizomeric restriction-modification systemHgiBI fromHerpetosiphon giganteus Hpg5: M.HgiBl reveals high homology to M.Banl

1991 • 20 citations

Construction of a Neisseria gonorrhoeae MS11 derivative deficient in NgoMI restriction and modification

1992 • 20 citations

A single amino acid change restores DNA Cytosine methyltransferase activity in a cloned chlorella virus pseudogene

1992 • 19 citations

Stepwise cloning and molecular characterization of theHgiDI restriction-modification system fromHerpetosiphon giganteus Hpa2

1991 • 19 citations

The M·AluI DNA-(cytosineC5)-methyltransferase has an unusually large, partially dispensable, variable region

1993 • 18 citations

Cloning and Nucleotide Sequences of the Ban Restriction-Modification Genes in Bacillus aneurinolyticus

1990 • 17 citations

Complementation by detached parts of GGCC-specific DNA methyltransferases

1991 • 17 citations

Stepwise cloning and genetic organization of the seemingly unclonable HgiCII restriction-modification system from Herpetosiphon giganteus strain Hpg9, using PCR technique

1992 • 14 citations

Cloning and molecular characterization of the HgiCI restriction/modification system from Herpetosiphon giganteus Hpg9 reveals high similarity to BanI

1991 • 14 citations

Cloning, sequence and characterization of m5C-methyltransferase-encoding gene, hgiDIIM (GTCGAC), from Herpetosiphon giganteus strain Hpa2

1991 • 13 citations

Cloning and structure of theBepI modification methylase

1989 • 13 citations