RhoE function is regulated by ROCK I-mediated phosphorylation

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

ROCKs: multifunctional kinases in cell behaviour

2003 • 1,866 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

2001 • 1,239 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle

2000 • 599 citations

Roles of PDGF in animal development

2003 • 570 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

RhoE Binds to ROCK I and Inhibits Downstream Signaling

2003 • 300 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

2003 • 237 citations

cGMP-Dependent Protein Kinase Phosphorylates and Inactivates RhoA

2001 • 218 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

Inhibition of Rho‐kinase‐induced myristoylated alanine‐rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H‐1152, a novel and specific Rho‐kinase inhibitor

2002 • 159 citations

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.

1987 • 128 citations

Mildly Oxidized Low Density Lipoprotein Induces Contraction of Human Endothelial Cells through Activation of Rho/Rho Kinase and Inhibition of Myosin Light Chain Phosphatase

1999 • 120 citations

RhoE Inhibits Cell Cycle Progression and Ras-Induced Transformation

2004 • 115 citations

Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets

1989 • 110 citations

Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation

2001 • 106 citations

Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

2000 • 104 citations

Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II

1997 • 92 citations

Rho Kinase Regulates the Intracellular Micromechanical Response of Adherent Cells to Rho Activation

2004 • 87 citations

Relative Platelet-derived Growth Factor Receptor Subunit Expression Determines Cell Migration to Different Dimeric Forms of PDGF

1990 • 87 citations

On the mitogenic properties of Rap1b: cAMP-induced G ₁ /S entry requires activated and phosphorylated Rap1b

2002 • 75 citations

Phosphorylation of Critical Serine Residues in Gem Separates Cytoskeletal Reorganization from Down-Regulation of Calcium Channel Activity

2003 • 72 citations

Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain

2002 • 63 citations

Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Kinase 1/2 Is Required for Hepatocyte Growth Factor-induced Cell Motility

2002 • 62 citations

PKC is required for activation of ROCK by RhoA in human endothelial cells

2003 • 47 citations

Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells

2003 • 44 citations

Crystal Structure of the Core Domain of RhoE/Rnd3: A Constitutively Activated Small G Protein^,

2002 • 25 citations