Inhibition of Rho‐kinase‐induced myristoylated alanine‐rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H‐1152, a novel and specific Rho‐kinase inhibitor

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

An essential part for Rho–associated kinase in the transcellular invasion of tumor cells

1999 • 609 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

1999 • 359 citations

Phosphorylation of Collapsin Response Mediator Protein-2 by Rho-kinase

2000 • 315 citations

A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages.

1995 • 303 citations

Activation of RhoA by Lysophosphatidic Acid and Gα_12/13Subunits in Neuronal Cells: Induction of Neurite Retraction

1999 • 303 citations

Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

1999 • 300 citations

A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

2000 • 289 citations

Rho-Kinase Inhibitor Retards Migration and in Vivo Dissemination of Human Prostate Cancer Cells

2000 • 234 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

2000 • 210 citations

Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

2000 • 177 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

Relaxation of Contracted Rabbit Tracheal and Human Bronchial Smooth Muscle by Y-27632 through Inhibition of Ca^{2 +} Sensitization

1999 • 164 citations

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

1999 • 159 citations

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase

1989 • 132 citations

Cellular and Molecular Actions of Lamotrigine: Possible Mechanisms of Efficacy in Bipolar Disorder

1998 • 130 citations

Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632

2001 • 118 citations

Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain

1990 • 116 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release

1991 • 104 citations

Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase

1999 • 101 citations

A Role for Rho-kinase in Rho-controlled Phospholipase D Stimulation by the m3 Muscarinic Acetylcholine Receptor

1999 • 83 citations

Glutamate Exocytosis and MARCKS Phosphorylation Are Enhanced by a Metabotropic Glutamate Receptor Coupled to a Protein Kinase C Synergistically Activated by Diacylglycerol and Arachidonic Acid

1994 • 79 citations

Distribution of Rho-Kinase in the Bovine Brain

1999 • 77 citations

Is Pharmacological Neuroprotection Dependent on Reduced Glutamate Release?

2000 • 76 citations

Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation*

2000 • 75 citations

Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N)

1998 • 73 citations

Myristoylated alanine-rich C kinase substrate (MARCKS), a major protein kinase C substrate, is an in vivo substrate of proline-directed protein kinase(s). A mass spectroscopic analysis of the post-translational modifications

1994 • 73 citations

Chromaffin Cell F-actin Disassembly and Potentiation of Catecholamine Release in Response to Protein Kinase C Activation by Phorbol Esters Is Mediated through Myristoylated Alanine-rich C Kinase Substrate Phosphorylation

2001 • 71 citations

Comparative distribution of myristoylated alanine-rich C kinase substrate (MARCKS) and F1/GAP-43 gene expression in the adult rat brain

1997 • 60 citations

Chapter 14: Transmitter release: target of regulation by protein kinase C?

1991 • 58 citations

Activation of Protein Kinase C‐α and Translocation of the Myristoylated Alanine‐Rich C‐Kinase Substrate Correlate with Phorbol Ester‐Enhanced Noradrenaline Release from SH‐SY5Y Human Neuroblastoma Cells

1997 • 50 citations

Rho-Associated Kinase Phosphorylates MARCKS in Human Neuronal Cells

2001 • 48 citations

Phosphorylation-dependent Conformational Changes Induce a Switch in the Actin-binding Function of MARCKS

1999 • 42 citations

Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.

1997 • 38 citations

Phosphorylation of synapsin I and MARCKS in nerve terminals is mediated by Ca²⁺ entry via an Aga‐GI sensitive Ca²⁺ channel which is coupled to glutamate exocytosis

1994 • 32 citations

Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells

1993 • 22 citations

The effect of ionophores on phosphate and arsenate transport in Micrococcus lysodeikticus

1977 • 15 citations

Overexpression of the myristoylated alanine‐rich C kinase substrate decreases uptake and K⁺‐evoked release of noradrenaline in the human neuroblastoma SH‐SY5Y

2001 • 10 citations

Phosphorylation of bovine brain 81-kDa acidic calmodulin binding protein (ACAMP-81) in vitro

1991 • 5 citations