cGMP-Dependent Protein Kinase Phosphorylates and Inactivates RhoA

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Defective smooth muscle regulation in cGMP kinase I-deficient mice

1998 • 510 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.

1990 • 327 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins

1989 • 258 citations

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I

1999 • 228 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Cyclic GMP-Dependent Stimulation Reverses G-Protein-Coupled Inhibition of Smooth Muscle Myosin Light Chain Phosphatase

1996 • 156 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase

1999 • 101 citations

Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation

1998 • 101 citations

cDNA Cloning and Gene Expression of Human Type Iα cGMP-Dependent Protein Kinase

1996 • 74 citations