Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

1989 • 520 citations

Spontaneous transformation and immortalization of human endothelial cells

1990 • 428 citations

Pharmacology and Toxicology of the Monovalent Carboxylic Ionophores

1982 • 311 citations

Agonist‐stimulated divalent cation entry into single cultured human umbilical vein endothelial cells.

1990 • 280 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Relationship of thyrotropin-releasing hormone-induced spike and plateau phases in cytosolic free Ca2+ concentrations to hormone secretion. Selective blockade using ionomycin and nifedipine.

1984 • 226 citations

Characterization of the Bradykinin-stimulated Calcium Influx Pathway of Cultured vascular Endothelial Cells

1989 • 224 citations

Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells

1990 • 207 citations

Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca2+-influx pathway

1992 • 190 citations

Inositol phosphates and Ca ²⁺ entry: toward a proliferation or a simplification?

1992 • 184 citations

Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.

1991 • 171 citations

Receptor‐mediated calcium entry

1990 • 127 citations

Simultaneous presence of two distinct endoplasmic-reticulum-type calcium-pump isoforms in human cells. Characterization by radio-immunoblotting and inhibition by 2,5-di-(t-butyl)-1,4-benzohydroquinone

1992 • 106 citations

Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores

1991 • 100 citations

Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry

1992 • 97 citations

Characteristics of inositol trisphosphate-mediated Ca2+ release from permeabilized hepatocytes.

1986 • 94 citations

Actions of vasopressin and the Ca(2+)-ATPase inhibitor, thapsigargin, on Ca2+ signaling in hepatocytes.

1992 • 87 citations

Bradykinin-induced Ca2+ entry, release, and refilling of intracellular Ca2+ stores. Relationships revealed by image analysis of individual human fibroblasts.

1992 • 87 citations

Dissociation of Ca2+ entry and Ca2+ mobilization responses to angiotensin II in bovine adrenal chromaffin cells

1989 • 86 citations

Histamine‐induced inward currents in cultured endothelial cells from human umbilical vein

1988 • 85 citations

Ca2+ influx induced by the Ca2+-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells

1992 • 69 citations

Activation of protein kinase C in human neutrophils attenuates agonist-stimulated rises in cytosolic free Ca2+ concentration by inhibiting bivalent-cation influx and intracellular Ca2+ release in addition to stimulating Ca2+ efflux

1989 • 68 citations

Effect of membrane potential on divalent cation transport catalyzed by the “electroneutral” ionophores A23187 and ionomycin

1989 • 66 citations

Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells

1993 • 64 citations

Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells

1986 • 64 citations

Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes

1993 • 58 citations

Uptake of Ca2+ and refilling of intracellular Ca2+ stores in Ehrlich-ascites-tumour cells and in rat thymocytes

1990 • 57 citations

Inositol phosphates and calcium entry.

1992 • 45 citations

Regulation of Ca2+ influx in myeloid cells. Role of plasma membrane potential, inositol phosphates, cytosolic free [Ca2+], and filling state of intracellular Ca2+ stores.

1992 • 43 citations

Econazole inhibits thapsigargin-induced platelet calcium influx by mechanisms other than cytochrome P-450 inhibition

1993 • 41 citations

Agonist-sensitive calcium pool in the pancreatic acinar cell. II. Characterization of reloading

1988 • 37 citations

Mobilization of intracellular calcium by extracellular ATP and by calcium ionophores in the Ehrlich ascites-tumour cell

1988 • 35 citations

SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells

1992 • 33 citations

Thapsigargin reveals evidence for fMLP-insensitive calcium pools in human leukocytes

1992 • 31 citations

Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1993 • 30 citations

The mechanism of activation of plasminogen at the fibrin surface by tissue-type plasminogen activator in a plasma milieu in vitro. Role of α2-antiplasmin

1990 • 30 citations

The formation constants of ionomycin with divalent cations in 80% methanol/water

1991 • 20 citations

Thrombin attenuates the stimulatory effect of histamine on Ca2+ entry in confluent human umbilical vein endothelial cell cultures

1991 • 19 citations

Dissociation of store release from transmembrane influx of calcium in human neutrophils

1992 • 17 citations

Permeation and inactivation by calcium and manganese of bovine adrenal chromaffin cell calcium channels

1992 • 14 citations

Refilling of endothelial calcium stores without bypassing the cytosol

1990 • 12 citations

Activation of calcium entry by cyclopiazonic acid in thyroid FRTL-5 cells

1993 • 11 citations