Chronic Immunodeficiency in Mice Lacking RasGRP1 Results in CD4 T Cell Immune Activation and Exhaustion

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

2006 • 3,361 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Memory CD8 T-Cell Differentiation during Viral Infection

2004 • 841 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

HIV disease: fallout from a mucosal catastrophe?

2006 • 578 citations

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

2004 • 489 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

2000 • 301 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

Regulation of mature T cell homeostasis

2005 • 191 citations

Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

2004 • 187 citations

The molecular program induced in T cells undergoing homeostatic proliferation

2004 • 176 citations

Autoimmunity during lymphopenia: A two-hit model

2006 • 176 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

2002 • 153 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Coordinate Analysis of Murine Immune Cell Surface Markers and Intracellular Phosphoproteins by Flow Cytometry

2005 • 134 citations

T cell homeostasis in tolerance and immunity

2005 • 128 citations

TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells

2001 • 91 citations

RETRACTED: Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1

2003 • 74 citations

BB rat lyp mutation and Type 1 diabetes

2001 • 65 citations

Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection.

1995 • 44 citations

The Lymphopenic Mouse in Immunology: From Patron to Pariah

2006 • 24 citations

RasGRP1 Transmits Prodifferentiation TCR Signaling That Is Crucial for CD4 T Cell Development

2006 • 22 citations